(A) Body weight (g). (A) Body weight (g). T2DM: n=6 per group. *p<0.001 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. (B) Kidney weight (g). T2DM: n=6.

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Key clinical efficacy outcomes for (A) hemoglobin A1c (HbA1c), (B) weight change. Key clinical efficacy outcomes for (A) hemoglobin A1c (HbA1c), (B) weight.

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(A) Body weight (g). (A) Body weight (g). T2DM: n=6 per group. *p<0.001 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. (B) Kidney weight (g). T2DM: n=6 per group. *p<0.001 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. *p<0.001 vs WT. (C) Kidney/body weight ratio (×1000). T2DM: n=6 per group. *p<0.001 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. *p<0.001 vs WT. (D) Serum BUN. T2DM: n=5 per group. *p<0.009 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. *p<0.031 vs WT; †p<0.001 vs Akita. (E) Serum creatinine. T2DM: n=5 per group. *p<0.003 vs WT; †p<0.001 vs BTBR. T1DM: n=5 per group. *p<0.035 vs WT; †p<0.001 vs Akita. T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; WT, wild-type. Yochai Birnbaum et al. BMJ Open Diab Res Care 2016;4:e000227 ©2016 by American Diabetes Association