Radiological and pathological findings in a common variable immunodeficiency patient with granulomatous-lymphocytic interstitial lung disease. a) High-resolution.

Slides:

Advertisements

Similar presentations

Positron Emission Tomography-Positive Squalene-induced Lipoid Pneumonia Confirmed by Gas Chromatography–Mass Spectrometry of Bronchoalveolar Lavage Fluid

Advertisements

Illustration of a pure ground-glass nodule which developed a solid component. a) June 2004; b) October 2004; c) June 2005; d) July Illustration of.

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.

Pathological alterations in idiopathic pulmonary fibrosis (IPF).

a-d) Typical changes over time in different diffuse lung diseases

Pathological changes in chronic obstructive pulmonary disease

Incidental finding of a nodular lesion in the right upper lobe

Surgical Lung Biopsy in Transplant Patients With Diffuse Lung Disease: How Much Worse When the Lung Is the Graft? Alejandro Bertolotti, MD, Sebastián.

Radiology assessment of pulmonary amyloidosis

Pleural thymoma: Radiological and histological findings

A) Chest radiograph, b) multislice computed tomography angiography, c) three-dimensional magnetic resonance angiography, d) perfusion scintigraphy and.

A) Pulmonary veno-occlusive disease (PVOD) with partial thrombotic occlusion of the lumen of a medium-sized vein (haematoxylin and eosin stain, 200× original.

A) Axial computed tomography (CT) showing mild thickening of bronchial walls (arrows) in a woman with Sjögren's syndrome. b) Chronic cough and recurrent.

A, b, e, f) Computed tomography (CT) of the chest and c, d) positron emission tomography (PET) with 2-deoxy-2-[fluorine-18] fluoro-D-glucose (18F-FDG)

High-resolution chest computed tomography images of a patient with lymphangioleiomyomatosis, showing round-shaped, thin-walled cysts distributed diffusely.

Histopathological phenotypes in the lung allograft

High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.

a) Chest radiograph showing bilateral coarse interstitial shadowing

A) Usual interstitial pneumonia in a 69-year-old woman with primary Sjögren's syndrome. a) Usual interstitial pneumonia in a 69-year-old woman with primary.

Examples of distal lung disease in “atypical” severe asthma and differential diagnoses from video-assisted thoracoscopic surgery procured tissue. a) Small.

Axial computed tomography (CT) images a) at baseline and b) at a 12-month follow-up scan, in a patient with idiopathic pulmonary fibrosis (IPF). b) Note.

Extent of interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD. A simple stratification that utilises pulmonary function.

Different radiological “phenotypes” of bronchiectasis

Volume evaluation during follow-up allows the detection of nodule growth over a shorter period of time compared to diameter estimation. a) Computed tomography.

Coronal chest computed tomography scan showing multiple areas of central ground-glass opacity, surrounded by ring or crescentic-shape, dense air-space.

Control computed tomography of the nodular lesion in the right upper lobe after 3 months. a) Axial mediastinal window, b) axial lung window and c) coronal.

Serial computed tomography (CT) imaging for monitoring disease progression in patients with idiopathic pulmonary fibrosis. Serial computed tomography (CT)

Representative photomicrographs of individual bronchiolar lesions observed in surgical lung biopsy in patients with small airways disease. a) Cellular.

Smoking-related fibrosis with dense acellular fibrosis that frequently surrounds cystic emphysematous spaces, both in a) centrilobular (haematoxylin and.

Nonspecific interstitial pneumonia: high-resolution computed tomography images from a 46-year-old male patient who underwent lung transplantation. a) The.

Right sleeve pneumonectomy for T4 squamous cell carcinoma

Radiodiagnostic imaging

a) Accurate bronchial skeleton.

A) Pulmonary Langerhans’ cell histiocytosis (PLCH) is characterised by an increased number of CD1a+ Langerhans’ cells in the bronchiolar wall (200×). b)

Multiple (type 3) cyst-related primary lung malignancies presenting as cystic airspaces with asymmetrical or circumferential wall thickening. a, b) A 52-year-old.

Positron emission tomography scan in the axial plane performed in June 2007 showing intense and homogeneous increased uptake of 18-fluorodeoxyglucose within.

Pattern high-resolution computed tomography consistent with nonspecific interstitial pneumonia in a patient with histological diagnosis of usual interstitial.

Contrast-enhanced computed tomography (CT) of the chest; case two, 4 days after presentation. a) Axial CT image of the upper thorax at the level of the.

A) Respiratory bronchiolitis: the intra-alveolar accumulation of finely pigmented macrophages (smoker’s macrophages) (haematoxylin and eosin, 400×). a)

Positron emission tomography/computed tomography scans showed a mass lesion. a) Areas of cavitation were noted in the left lower lobe, encasing the segmental.

Evaluation of complications.

Limitations of two-dimensional (2D) measurements.

Elastic staining of paraffin-embedded lung tissue.

A) 18-fluorodeoxyglucose positron emission tomography-computed tomography in a 72-year-old male revealed pulmonary nodules in the lower lobes. a) 18-fluorodeoxyglucose.

Simplified diagram of the multidisciplinary process to diagnose interstitial lung disease, including a clinician, radiologist, pathologist and also a geneticist:

Endobronchial biopsy from case 2 showing sheets of epitheloid macrophages without giant cells, mixed with other chronic inflammatory cells. Endobronchial.

Initial non-contrast computed tomography (CT) of the chest and neck; case two. a) Axial CT image through the upper thorax shows fluid collections in the.

A) Chest radiograph at admission showing multiple bilateral nodular images, which are more abundant in the right lung. b) Chest computed tomography scan.

A) Positron emission tomography scan showing 18F-fluorodeoxyglucose uptake in the right supraclavicular, hilar and mediastinal lymph nodes and in the left.

Example of thin parenchymal section computed tomography findings in desquamative interstitial pneumonia: patchy ground-glass attenuation with a peripheral.

Chronic hypersensitivity pneumonitis with usual interstitial pneumonia pattern. a) At low magnification, bronchiolar damage with bridging fibrosis between.

Follow-up contrast-enhanced computed tomography (CT); case one, obtained 19 days after presentation. a) Axial CT of the neck at the level of the hyoid.

A) Axial and b) coronal computed tomography scans of usual interstitial pneumonia pattern in a patient with rheumatoid arthritis. a) Axial and b) coronal.

High-resolution computed tomography with nonspecific interstitial pneumonia pattern in a patient with connective tissue disease; bilateral reticulation.

A) Mucus replete left lower lobe bronchiectasis in a young X-linked agammaglobulinaemia patient (coronal and axial view). b) Pathogenesis of bronchiectasis.

Procedure for the diagnosis of interstitial lung diseases.

Investigation of suspected idiopathic pulmonary fibrosis: multidisciplinary team (MDT) discussion is a key component of the diagnostic pathway. Investigation.

High-resolution computed tomography from a patient with anti-Jo1 positive polymyositis showing basilar predominate reticulation and ground-glass opacity.

Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain and ×10 growth). Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain.

Images from a 62-year-old male patient presenting with a heterogeneous mass in the superior lobe of the right lung. a) Fusion of axial fat-saturated T1-weighted.

Open lung biopsy specimen showing an inflammation with thickened interalveolar septa and the inflammatory infiltration of mononuclear cells (areas of a.

Left upper lobe complete atelectasis 2 days after implantation of four endobronchial valves into the left upper lobe in a patient with emphysema. a) Chest.

Thoracic high-resolution computed tomography: predominant diffuse ground-glass opacities associated with a lymphatic distribution of micronodules with.

High-resolution computed tomography scan demonstrating a typical example of usual interstitial pneumonia pattern with honeycombing change and traction.

Diffusion weighted magnetic resonance imaging

High-resolution computed tomography images of smoking-related interstitial lung diseases (ILDs). a) Pulmonary Langerhans cell histiocytosis, b) respiratory.

High-resolution computed tomography (HRCT) images from a 75-year-old, male ex-smoker with combined pulmonary fibrosis and emphysema syndrome (CPFE). a)

A) Mucosa-associated lymphoid tissue lymphoma in a 45-year-old woman with primary Sjögren's syndrome. a) Mucosa-associated lymphoid tissue lymphoma in.

A) Smokers’ macrophages show a fine, golden haemosiderin cytoplasmic pigment; b) in respiratory bronchiolitis (RB), smokers’ macrophages are located in.

A) Chest computed tomography image showing left upper lobe cavitary lesion consistent with invasive pulmonary aspergillosis (IPA) in an allogeneic haematopoietic.

Presentation transcript:

Radiological and pathological findings in a common variable immunodeficiency patient with granulomatous-lymphocytic interstitial lung disease. a) High-resolution computed tomography: axial, coronal and sagittal views show several nodules with peri-lymphatic... Radiological and pathological findings in a common variable immunodeficiency patient with granulomatous-lymphocytic interstitial lung disease. a) High-resolution computed tomography: axial, coronal and sagittal views show several nodules with peri-lymphatic distribution without predominance in the upper lobes, and the co-existence of bronchiectasis. b) Positron emission tomography/computed tomography findings shows hilar lymph nodes and peri-lymphatic nodules on fluorodeoxyglycose (FDG) uptake, an inhomogeneous FDG uptake area of consolidation at the right lower lobe of the lung, and inhomogeneous liver and spleen FDG uptake with splenomegaly. Bone marrow activation images are also detectable. Bronchoalveolar lavage fluid cell analysis showed lymphocytosis (25%) with an increase in B-cells (73% were represented by CD21 low-activated B-cells). Lymphoproliferative disease was initially ruled out through trans-bronchial biopsy. Surgical lung biopsy examination was consistent with granulomatous-lymphocytic interstitial lung disease. Liver biopsy examination showed nodular lymphoid hyperplasia. c, d) Pathological findings from surgical lung biopsy. c) Bronchiolar and peri-bronchiolar inflammation with follicular bronchiolitis and contiguous parenchymal involvement (haematoxylin and eosin staining, ×25 original magnification). d) Microgranuloma with a giant cell surrounded by foamy and epithelioid macrophages (haematoxylin and eosin staining, ×200 original magnification). Francesco Cinetto et al. Eur Respir Rev 2018;27:180019 ©2018 by European Respiratory Society