A) RON tyrosine kinase receptor structure; highlighted are the two somatic mutations detected in brain secondary lesions from lung cancers (R1136C and.

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Presentation transcript:

a) RON tyrosine kinase receptor structure; highlighted are the two somatic mutations detected in brain secondary lesions from lung cancers (R1136C and P1162S) and R1335G polymorphism (NCBI rs1062633). b) Details on somatic mutations and recurrent single nuc... a) RON tyrosine kinase receptor structure; highlighted are the two somatic mutations detected in brain secondary lesions from lung cancers (R1136C and P1162S) and R1335G polymorphism (NCBI rs1062633). b) Details on somatic mutations and recurrent single nucleotide polymorphism (SNP). c) Bioinformatics prediction of pathogenic role of the changes found. IPT: immunoglobulin-plexin-transcription; PM: plasma membrane; SEMA: semaphorin; TK: tyrosine kinase. Melissa Milan et al. ERJ Open Res 2018;4:00083-2017 ©2018 by European Respiratory Society