Xiaoou Zhou, Malcolm K. Brenner Experimental Hematology

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Improving the safety of T-Cell therapies using an inducible caspase-9 gene Xiaoou Zhou, Malcolm K. Brenner Experimental Hematology Volume 44, Issue 11, Pages 1013-1019 (November 2016) DOI: 10.1016/j.exphem.2016.07.011 Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 1 Structure of the iC9 suicide gene. (A) The transgene consists of an inducible caspase-9 (iC9) and a selectable marker, truncated CD19 (ΔCD19), linked by a 2A-like sequence, which encodes a cleavable peptide. iC9 consists of a drug-binding domain (FKBP12-F36V) connected via a short linker (SGGGS) to human caspase-9. (B) Conditional caspase 9 dimerization is induced in the presence of CID (AP1903), cleaving caspase-3 and leading to cell apoptosis. Experimental Hematology 2016 44, 1013-1019DOI: (10.1016/j.exphem.2016.07.011) Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions