Immune modules shared by innate lymphoid cells and T cells

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Presentation transcript:

Immune modules shared by innate lymphoid cells and T cells Michelle L. Robinette, BS, Marco Colonna, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 5, Pages 1243-1251 (November 2016) DOI: 10.1016/j.jaci.2016.09.006 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Development of T cells and ILCs. T cells and ILCs both develop downstream of the common lymphoid progenitor (CLP). T-cell progenitors (left) undergo progressive developmental stages in the thymus, which ultimately result in export of naive CD8+ and CD4+ T cells to the periphery. In contrast, ILC generation (right) occurs in the bone marrow through a series of progenitors with increasingly restricted developmental potential, resulting in export of lineage-specified ILCs directly to the periphery. The sequences of recognized ILC progenitors are indicated in black in the bone marrow, whereas presumed progenitors are denoted by question marks. Journal of Allergy and Clinical Immunology 2016 138, 1243-1251DOI: (10.1016/j.jaci.2016.09.006) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Effector modules of T cells and ILCs. In the periphery naive T cells (left) that recognize their specific antigen and are costimulated by antigen-presenting cells become activated and mature to effector cells. For CD4+ T cells, antigen-presenting cell–derived cytokines drive STAT activation and TF induction, leading to TH polarization and the indicated effector functions. Meanwhile, ILCs in the periphery are already mature cells that do not require STAT activation to develop, although STATs are important for some ILC effector functions. The TFs required for TH polarization and ILC development and the effector functions of cells in the same module are strikingly similar. ILC counterparts to follicular helper T (Tfh) and Treg cells are not currently recognized. Journal of Allergy and Clinical Immunology 2016 138, 1243-1251DOI: (10.1016/j.jaci.2016.09.006) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions