Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva

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Presentation transcript:

A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva Clinical Gastroenterology and Hepatology Volume 15, Issue 12, Pages 1940-1949.e8 (December 2017) DOI: 10.1016/j.cgh.2017.04.016 Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Trial profile. NAS, nonalcoholic fatty liver disease activity score. Clinical Gastroenterology and Hepatology 2017 15, 1940-1949.e8DOI: (10.1016/j.cgh.2017.04.016) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 2 Changes in the nonalcoholic fatty liver disease activity score (NAS) of individual patients. Mean change in the NAS in the silymarin group vs the placebo group for patients with fibrosis improvement (–1.455 vs –2.333; P = .226). Mean change in the NAS in the silymarin group vs the placebo group for patients without fibrosis improvement (–0.447 vs –0.617; P = .654). Mean change in the NAS in patients with fibrosis improvement vs without fibrosis improvement in the silymarin group (–1.455 vs –0.447; P = .023). Mean change in the NAS in patients with fibrosis improvement vs without fibrosis improvement in the placebo group (–2.333 vs –0.617; P = .019). Clinical Gastroenterology and Hepatology 2017 15, 1940-1949.e8DOI: (10.1016/j.cgh.2017.04.016) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 3 Line charts illustrating the changes in the (A) aspartate aminotransferase to platelet ratio index (APRI), (B) fibrosis-4 (FIB-4) score, and (C) nonalcoholic fatty liver disease (NAFLD) fibrosis scores in the silymarin group and in the placebo group. Clinical Gastroenterology and Hepatology 2017 15, 1940-1949.e8DOI: (10.1016/j.cgh.2017.04.016) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 4 Line charts illustrating the changes in the (A) alanine aminotransferase and (B) aspartate aminotransferase in the silymarin group and in the placebo group. Clinical Gastroenterology and Hepatology 2017 15, 1940-1949.e8DOI: (10.1016/j.cgh.2017.04.016) Copyright © 2017 AGA Institute Terms and Conditions