Spectral-Polarization Sensors for in vivo Oncology Imaging [1] M. Kulkarni and V. Gruev, "Integrated spectral-polarization imaging sensor with aluminum nanowire polarization filters," Optics Express, vol. 20, pp. 22997-23012, 2012 [2] Y. Liu, R. Njuguna, T. Matthews, W. Akers, G. Sudlow, S. Mondal, R. Tang, V. Gruev and S. Achilefu, "Near-infrared Fluorescence Goggle System with CMOS Imaging Sensor and See-Through Display," Journal of Biomedical Optics, 2013. Integrating CMOS technology with nano-materials can lead to novel, super-sensitive imagers Aluminum and dielectric nanowires can be designed to have spectral and polarization filtering properties Integration of nano-materials with CMOS technology allows for compact and wearable imagers Custom signal processing algorithms allow for enhanced imaging of cancerous tissue Major challenge has been bringing this technology to the operating room The technology is currently in clinical trials This technology is helping surgeons ensure that all cancerous cells are removed from a patient CMOS Pixels SEM Image of Al nanowires Color Image Near Infrared Image Enhanced Image Ex vivo Imaging Using our camera in the operating room