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Volume ():bjgpfeb-2017-67-655-taylor-fl-oa-p Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study by Clare J Taylor, Andrea K Roalfe, Rachel Iles, FD Richard Hobbs, , Pelham Barton, Martin R Cowie, Russell C Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, and Lynda Tait BJGP Volume ():bjgpfeb-2017-67-655-taylor-fl-oa-p December 5, 2016 ©2016 by British Journal of General Practice

Flow diagram to show number of participants in REFER study. Flow diagram to show number of participants in REFER study. Step 1 = clinical info +ECG+echo. Step 2 = CDR variables. Step 3 = NT–proBNP result. CDR = clinical decision rule. DNA = did not attend. NT-proBNP = N-Terminal pro-B type natriuretic peptide levels. Clare J Taylor et al. Br J Gen Pract doi:10.3399/bjgp16X688393 ©2016 by British Journal of General Practice

Receiver operating characteristic curves of CDR+NT-proBNP or NT-proBNP alone for predicting heart failure. Receiver operating characteristic curves of CDR+NT-proBNP or NT-proBNP alone for predicting heart failure. CDR = clinical decision rule. NT-proBNP = N-Terminal pro-B type natriuretic peptide levels. Clare J Taylor et al. Br J Gen Pract doi:10.3399/bjgp16X688393 ©2016 by British Journal of General Practice

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