S. Godreuil, F. Renaud, M. Choisy, J. J. Depina, E. Garnotel, M

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Highly structured genetic diversity of the Mycobacterium tuberculosis population in Djibouti S. Godreuil, F. Renaud, M. Choisy, J.J. Depina, E. Garnotel, M. Morillon, P. Van de Perre, A.L. Bañuls Clinical Microbiology and Infection Volume 16, Issue 7, Pages 1023-1026 (July 2010) DOI: 10.1111/j.1469-0691.2009.03025.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 UPGMA tree based on combined data, spoligotypes and mycobacterial interspersed repetitive-unit variable-number tandem-repeats (MIRU-VNTR) (24 loci) of the 62 samples under study (a Mycobacterium canettii stock was used as outgroup (a)). The relationships among patterns were assessed using the UPGMA dendrogram. The spoligotypes listed correspond to the designation in the SpolDB4 database ((b)Mycobacterium tuberculosis complex (MTBC) lineages) and lineages were determined using SpolDB4 rules [7]. Unknown patterns match none of the spoligotypes described in the SpolDB4 database. (c) MIRU-VNTR patterns for the 24 loci and for each isolate are displayed in each line. The columns correspond to the MIRU-VNTR loci in the following order: MIRU02, VNTR0424, ETR C, MIRU04, MIRU40, MIRU10, MIRU16, MIRU20, VNTR1955, MIRU23, MIRU24; MIRU26, MIRU27, MIRU31, MIRU39, ETR A, QUB-11b, VNTR2347, VNTR3171, QUB-26, VNTR2401, VNTR3690, VNTR4156, and ETR B. Clinical Microbiology and Infection 2010 16, 1023-1026DOI: (10.1111/j.1469-0691.2009.03025.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Distribution of the posterior probabilities of a strain in the total number of tuberculosis (TB) cases belonging to one of the three observed lineages (marked 1, 2 and 3 for the EAI, T and CAS groups of Fig. 1) or none of them (marked 0). The vertical full lines are the observed proportions, and the vertical dashed lines are the posterior means obtained using a uniform prior distribution. Clinical Microbiology and Infection 2010 16, 1023-1026DOI: (10.1111/j.1469-0691.2009.03025.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions