Parental smoking impairs vaccine responses in children with atopic genotypes Gareth Baynam, MBBS, Siew-Kim Khoo, BSc, Julie Rowe, PhD, Guicheng Zhang,

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Presentation transcript:

Parental smoking impairs vaccine responses in children with atopic genotypes Gareth Baynam, MBBS, Siew-Kim Khoo, BSc, Julie Rowe, PhD, Guicheng Zhang, PhD, Ingrid Laing, PhD, Catherine Hayden, PhD, Merci Kusel, PhD, Nick DeKlerk, PhD, Peter Sly, DM, Jack Goldblatt, MD, Patrick Holt, DSc, Peter LeSouef, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 2, Pages 366-374 (February 2007) DOI: 10.1016/j.jaci.2006.09.018 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Specific IgG responses to diphtheria toxoid categorized by IL-4 C-589T genotype (∗P < .05). Log geometric mean (GM) and 95% CI are plotted. Numbers on the horizontal axis are the numbers of individuals within each genotype group. The gray bar represents atopic genotypes. Values plotted are corrected for time between last dose of vaccine and blood collection. Journal of Allergy and Clinical Immunology 2007 119, 366-374DOI: (10.1016/j.jaci.2006.09.018) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Specific IgG responses to diphtheria and tetanus toxoids compared between IL-4Rα Q551R genotypes in subjects exposed (PS) and unexposed (no PS) to PS (∗P < .05). Log geometric mean (GM) and 95% CI are plotted. Numbers on the horizontal axis are the number of individuals within each genotype group. Gray bars represent atopic genotypes. Values plotted are corrected for time between last dose of vaccine and blood collection. Journal of Allergy and Clinical Immunology 2007 119, 366-374DOI: (10.1016/j.jaci.2006.09.018) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Tetanus toxoid–stimulated cytokine responses compared between IL-4Rα Q551R genotypes in subjects exposed to PS (∗P < .05). Log geometric mean (GM) and 95% CI are plotted. Numbers on the horizontal axis are the numbers of individuals within each genotype group. Gray bars represent atopic genotypes. Values plotted are corrected for time between last dose of vaccine and blood collection. Journal of Allergy and Clinical Immunology 2007 119, 366-374DOI: (10.1016/j.jaci.2006.09.018) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 PHA- and SEB-induced cytokine responses compared between IL-4Rα Q551R genotypes in subjects exposed to PS (∗P < .05). Log geometric mean (GM) and 95% CI are plotted. Gray bars represent atopic genotypes. Numbers on the horizontal axis are the numbers of individuals within each genotype group. Journal of Allergy and Clinical Immunology 2007 119, 366-374DOI: (10.1016/j.jaci.2006.09.018) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Lipoteichoic acid (LTA) and pansorbin-induced (Pan) cytokine responses compared between IL-4Rα Q551R genotypes in subjects exposed to PS (∗P < .05). Log geometric mean and 95% CI are plotted. Gray bars represent atopic genotypes. Numbers on the horizontal axis are the numbers of individuals within each genotype group. Journal of Allergy and Clinical Immunology 2007 119, 366-374DOI: (10.1016/j.jaci.2006.09.018) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions