21 October 2009 This Week in Physiology: Wednesday Quiz: Cranial Nerves Lab: Sensory Physiology & Auditory System Lectures: Ch. 9 Muscle Physiology Starting Wednesday after Fall Break: 1 Question Quiz each class meeting based on the previous lecture.
Energy for powerstroke & Necessary for detaching myosin from actin Fig. 09.08 2 roles of ATP: Energy for powerstroke & Necessary for detaching myosin from actin Crossbridge cycling continues as long as ATP and Ca++ present. 09.08.jpg
YouTube Videos Role of ATP in muscle Creepy Muscle demo Sarcomere contraction Powerstoke in muscle I Powerstroke in muscle II 09.09.jpg
Muscle kinetics Link to cytosolic calcium concentration, release, and reuptake? 09.10.jpg
Fig. 09.16 09.16.jpg
Fig. 09.19a Twitch Twitch Twitch 09.19a.jpg
Fig. 09.19b Summation 09.19b.jpg Tension is a result of the temporal control of cytosolic calcium concentration
Fig. 09.19c 09.19c.jpg
Fig. 09.20 Why does this plateau? 09.20.jpg So….. Tension produced by a single myofiber varies depending on frequency of Action Potentials.
Length-tension Relationship 09.21.jpg So….. Tension produced by a single myofiber varies depending on sarcomere length.
So what are the ways a muscle (consisting of many myofibers) increases tension (force)?
Fig. 09.13 Motor unit = a single somatic motor neuron and all the muscle fibers in innervates 09.13.jpg
Increasing tension in a whole muscle Frequency of stimulation of motor neuron Activate larger motor units Recruitment: activate more motor units These factors influence actual tension Fiber length (length-tension) relationship Fiber diameter Level of fatigue (state of activity)