Crash Course on Extending the Human Lifespan

What can shorten a human lifespan?

Cardiovascular Disease Communicable Diseases Diseases of old age – Cell atrophy: arthritis, Huntington's, Multiple Sclerosis – Mental: Alzheimer's, dementia, etc. Cancer

Deaths in 2004 according to the WHO TOTAL Deaths Cause# of deaths % of total deaths Cardiovascular diseases Respiratory diseases Diabetes mellitus Infectious and parasitic diseases Respiratory infections Neuropsychiatric disorders Alzheimer and other dementias Parkinson disease Malignant neoplasms Solutio n Reversatrol Rapamycin SENS Proposal All Three

Shortened lifespan due to lifestyle TOTAL Deaths Cause# of deaths % of total deaths Cardiovascular diseases Respiratory diseases Diabetes mellitus Solutio n Reversatrol Cardiovascular and Respiratory diseases, and Type 2 Diabetes were responsible for 37.8% of deaths in These problems arise from lifestyle choices; obesity, unhealthy diet, smoking, uncontrolled blood pressure and blood sugar, etc.

Solution to Lifestyle: Reversatrol Calorie restricted diet American diet WITH Reversatrol American diet WITHOUT Reversatrol Normal BP Healthy Metabolism Good endurance Normal BP Healthy Metabolism Good endurance High BP Unhealthy Metabolism No endurance

Solution to Lifestyle: Reversatrol Reduced heart disease, diabetes, lower BP Will most likely die from heart disease, diabetes, or high BP Reduced heart disease, diabetes, lower BP Calorie restricted diet American diet WITH Reversatrol American diet WITHOUT Reversatrol

Shortened lifespan due to Infections TOTAL Deaths Cause# of deaths % of total deaths Infectious and parasitic diseases Respiratory infections Solutio n SENS Proposal Infectious diseases and respiratory infections were responsible for 23.4% of deaths in These infections arose from two main sources; Unavailability of vaccines (poor countries) and the bodies regular immune system being just not good enough

Solution to Infections: SENS Proposal Transpantation and Tissue Engineering – Infections of organs Cell Therapy – Eliminates infections of (and non-performance) cells Germline Therapy – Altering a zygote so that an organism can grow from birth with DNA that is unable to mutate Sens & sens research; delivery. (2010). Retrieved from

Shortened lifespan due to Old Age Solutio n Degenerative and psychiatric diseases were responsible for more than 3.1% of deaths in These problems arise from genetics and cell atrophy (cell death) TOTAL Deaths Cause# of deaths % of total deaths Neuropsychiatric disorders Alzheimer and other dementias Parkinson disease Rapamycin

Solution to Cell Atrophy: Rapamycin Immunosuppressive therapy to help prevent organ rejection in transplant patients. Only showed life extending qualities when introduced in old age. Why?

Solution to Cell Atrophy: Rapamycin Immunosuppressive therapy to help prevent organ rejection in transplant patients. Only showed life extending qualities when introduced in old age Rapamycin has an effect on the telomere – Slows cell atrophy by extending the telomeres of DNA

Shortened lifespan due to Cancer Solutio n Cancer was responsible for than 12.6% of deaths in Cancer arises from…? A combination of obesity, unhealthy diet, smoking, uncontrolled blood pressure and blood sugar, bodies regular immune system being just not good enough, genetics and cell atrophy (cell death) Use of all three proposals TOTAL Deaths Cause# of deaths % of total deaths Malignant neoplasms

Solution to Cancer: combination of all 3 new technologies Using Reversatrol, the SENS Proposal, and Rapamycin, we can greatly reduce our exposure and risk to mutations of our cells (cancer)

Reversatrol on Cancer Obesity, high blood pressure, high blood sugar, and the physiological effects of an unhealthy lifestyle can be eliminated, which reduces chances of mutated cells Obviously, this does not apply to smoking or eating asbestos.

The SENS Proposal on Cancer Transpantation and Tissue Engineering for effected organs/tissue Germline Therapy applied so that the DNA cannot mutate

Rapamycin on Cancer Cancer takes advantage of the Telomere of cells and can actually keep the cells alive to reproduce the mutated DNA Applying Rapamycin backwards, we could treat cancerous cells by targeting their telomere supplies