Prenatal and postnatal genetic influence on lung function development

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Presentation transcript:

Prenatal and postnatal genetic influence on lung function development Eskil Kreiner-Møller, MD, Hans Bisgaard, MD, DMSci, Klaus Bønnelykke, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 5, Pages 1036-1042.e15 (November 2014) DOI: 10.1016/j.jaci.2014.04.003 Copyright © 2014 Terms and Conditions

Fig 1 Relationship between genetic risk score (calculated from SNPs associated with adult FEV1/FVC) and FEF50 in the COPSAC2000 cohort. Distributions of genetic risk scores are shown as bars, with the number of subjects in each category on the left y-axis. A, Relationship between mean genetic risk score and growth of FEF50 from birth to 7 years of age as the z score FEF50 value at age 7 years calibrated for neonatal FEF50 shown as solid circles on the right y-axis. B, Relationship between mean genetic risk score and FEF50 measurements at age 7 years shown as solid circles on the right y-axis. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig 2 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1/FVC ratio and relationship to the following measures at age 7 years: FEF50 (A), FEV1/FVC ratio (B), PD20 (C), FEF50 growth (D), and PD15/20 growth (E). P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E1 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1/FVC and relationship to the different lung function and bronchial responsiveness measures at birth and at age 7 years. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E2 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1/FVC and relationship to the different lung function and bronchial responsiveness measures at birth and at age 7 years adjusted for asthma. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E3 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1/FVC and relationship to the growth of lung function and bronchial responsiveness. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E4 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1/FVC and relationship to the growth of lung function and bronchial responsiveness adjusted for asthma. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E5 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1 and relationship to the different lung function and bronchial responsiveness measures at birth and at age 7 years. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E6 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1 and relationship to the growth of lung function and bronchial responsiveness. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E7 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1 and relationship to the different lung function and bronchial responsiveness measures at birth and at age 7 years adjusted for asthma. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions

Fig E8 Observed P values plotted against P values expected under the null hypothesis of SNPs previously shown to be of importance to adult FEV1 and relationship to the growth of lung function and bronchial responsiveness adjusted for asthma. P values printed within each plot reflect enrichment. Journal of Allergy and Clinical Immunology 2014 134, 1036-1042.e15DOI: (10.1016/j.jaci.2014.04.003) Copyright © 2014 Terms and Conditions