CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies Michael J. McGeachie, PhD, Ann.

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CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies Michael J. McGeachie, PhD, Ann C. Wu, MD, Sze Man Tse, MD, George L. Clemmer, MS, Joanne Sordillo, ScD, Blanca E. Himes, PhD, Jessica Lasky-Su, PhD, Robert P. Chase, MS, Fernando D. Martinez, MD, Peter Weeke, MD, Christian M. Shaffer, BS, Hua Xu, PhD, Josh C. Denny, MD, Dan M. Roden, MD, Reynold A. Panettieri, MD, Benjamin A. Raby, MD, Scott T. Weiss, MD, Kelan G. Tantisira, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1503-1510 (December 2015) DOI: 10.1016/j.jaci.2015.04.039 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 CAMP permutation versus joint CAMP–CARE Network P values from meta-analysis for the top GWAS SNPs. Stars indicate SNPs and are annotated with gene symbols in cases in which the SNP is within a gene. The diagonal line indicates x = y; SNPs that did not change P values from CAMP permutation testing to CAMP–CARE Network meta-analysis are close to this line. Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 CTNNA3 eQTL plot for rs10997296. The suspected regulatory SNP rs10997269 is labeled and highlighted with a purple diamond. rs7915695 is indicated with a black arrow. Other SNPs are colored with their LD to rs10997269 (r2), indicating a locus of SNPs nearby that might have action on CTNNA3 expression. The illustration was generated with LocusZoom. Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E8 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E9 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E10 Journal of Allergy and Clinical Immunology 2015 136, 1503-1510DOI: (10.1016/j.jaci.2015.04.039) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions