Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases Mübeccel Akdis, MD, PhD, Simone Burgler, PhD, Reto Crameri,

Slides:

Advertisements

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Monoclonal antibodies and fusion proteins in medicine

Doina M. Racila, MD, Joel N. Kline, MD, MSc

Barbara Stanic, PhD, Willem van de Veen, PhD, Oliver F

Defects of class-switch recombination

Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema Sabine Zeller, MSc, Claudio Rhyner, PhD, Norbert Meyer, MD, Peter.

Laurent L'homme, PhD, David Dombrowicz, PhD

Advances in food allergy in 2015

Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance Margot Berings, MD, Cagatay Karaaslan,

The role of viruses in acute exacerbations of asthma

Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.

Is 9 more than 2 also in allergic airway inflammation?

Histamine in the immune regulation of allergic inflammation

Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions Shelley F. Stone, PhD, Claire Cotterell,

T-cell regulation in chronic paranasal sinus disease

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells Kristine E. Nograles, MD,

David J. Cousins, PhD, Joanne McDonald, BSc, Tak H. Lee, MD, ScD

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

Immune modulation by neuronal electric shock waves

TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection Mübeccel Akdis, MD, PhD, Oscar Palomares, PhD,

Kristina Rueter, MD, Anderson P

Epithelium: At the interface of innate and adaptive immune responses

Immune modules shared by innate lymphoid cells and T cells

The future of allergy/immunology: Promising young investigators

An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1– related disease in children Kumud K. Singh, PhD, Alexis Lieser, MD,

Martin J. Romeo, PhD, Rachana Agrawal, PhD, Anna Pomés, PhD, Judith A

Inhibition of angiogenesis by IL-32: Possible role in asthma

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases Mübeccel Akdis,

Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species László Maródi, MD, PhD, Sophie Cypowyj, PhD, Beáta Tóth, PhD,

Awaiting allograft antigen: For rejection or tolerance?

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics Marek Jutel, MD, Ioana Agache, MD, Sergio Bonini,

The role of the T cell in asthma

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD

Mechanism-Based Precision Therapy for the Treatment of Primary Immunodeficiency and Primary Immunodysregulatory Diseases Jennifer W. Leiding, MD, Lisa.

Increased activation-induced cell death of high IFN-γ–producing TH1 cells as a mechanism of TH2 predominance in atopic diseases Tunc Akkoc, PhD, Pieter.

The eosinophil—quo vadis?

Autophagy: Nobel Prize 2016 and allergy and asthma research

Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy.

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy Fatimah Kussebi, MD, Fariba Karamloo, PhD, Claudio Rhyner,

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

Bart N. Lambrecht, MD, PhD, Hamida Hammad, PhD

Mechanisms of food allergy

Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments László Maródi, MD, PhD, Jean-Laurent.

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases Mübeccel Akdis,

TH9 immunodeficiency in patients with hyper-IgE syndrome

Does “autoreactivity” play a role in atopic dermatitis?

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell–mediated allergic inflammation Yong-Jun Liu, MD, PhD Journal.

Innate immune responses to infection

Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects Hiroyuki Fujita, MD, PhD, Maciej Chalubinski, MD, PhD,

Vitamin D in allergic disease: Shedding light on a complex problem

TH2 adjuvants: Implications for food allergy

The Editors' Choice Journal of Allergy and Clinical Immunology

Immune pathomechanism of drug hypersensitivity reactions

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy.

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses Willem van de Veen, MSc, Barbara.

Advances and highlights in mechanisms of allergic disease in 2015

The future of biologics: Applications for food allergy

Natural history of cow’s milk allergy

Alexander S. Kim, MD, Taylor A. Doherty, MD, Maya R

Primary prevention of asthma and allergy

Presentation transcript:

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases Mübeccel Akdis, MD, PhD, Simone Burgler, PhD, Reto Crameri, PhD, Thomas Eiwegger, MD, Hiroyuki Fujita, MD, PhD, Enrique Gomez, PhD, Sven Klunker, PhD, Norbert Meyer, MD, Liam O’Mahony, PhD, Oscar Palomares, PhD, Claudio Rhyner, PhD, Nadia Quaked, PhD, Anna Schaffartzik, PhD, Willem Van De Veen, MSc, Sabine Zeller, PhD, Maya Zimmermann, PhD, Cezmi A. Akdis, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 3, Pages 701-721.e70 (March 2011) DOI: 10.1016/j.jaci.2010.11.050 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, The receptors of the IL-2 family, which is composed of IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Receptors contain the common cytokine receptor γ chain (CD132, γc). IL-13R shares IL-4Rα with IL-4, and TSLPR shares IL-7R with IL-7. B, The receptors for IL-3, IL-5, and GM-CSF (GMR) are heterodimers of a unique α-chain and the common β-chain (βc, CD131) subunit. C, The receptors for IL-4 and IL-13 consists of 2 receptor chains, the IL-4Rα (CD124) and the common γc. IL-4 and IL-13 bind to IL-4R, which consists of the IL-4Rα and the IL-13Rα1 chain. IL-13R consists of 2 subunits, IL-13Rα1 and IL-13Rα2, and signaling occurs via the IL-4R complex type II that consists of the IL-4Rα and IL-13Rα. D, On the basis of similarities in their intron-exon structure, conserved secondary protein structures, and similar types of receptors, the following cytokines have been classified as IL-10 family members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. They share common receptor subunits shown. E, IL-12R consist of 2 subunits, IL-12Rβ1 and IL-12Rβ2.A heterodimer of IL-12Rβ1 and IL-23R bind IL-23. IL-12Rβ2 shows homology to the gp130 subunit of IL-27R. EBI3, Epstein-Barr virus-induced. Journal of Allergy and Clinical Immunology 2011 127, 701-721.e70DOI: (10.1016/j.jaci.2010.11.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Antigen presentation by DCs to naive T cells and other factors (innate immune response substances, vitamins, cytokines in the environment) induces the T cells to produce ILs and differentiate into Th1, Th2, Th9, Th17, Th22, or follicular Th (TFH) cells. These T-cell subsets can promote different types of inflammatory responses on the basis of their respective cytokine profiles, responses to chemokines, and interactions with other cells. Journal of Allergy and Clinical Immunology 2011 127, 701-721.e70DOI: (10.1016/j.jaci.2010.11.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions