Delayed detection of motor pathway dysfunction after selective reduction of thoracic spinal cord blood flow in pigs Jeroen Lips, BSa, Peter de Haan,

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Presentation transcript:

Delayed detection of motor pathway dysfunction after selective reduction of thoracic spinal cord blood flow in pigs Jeroen Lips, BSa, Peter de Haan, MD, PhDa, Gerrit J. Bouma, MD, PhDb, Michael J. Jacobs, MD, PhDc, Cor J. Kalkman, MD, PhDd The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 3, Pages 531-538 (March 2002) DOI: 10.1067/mtc.2002.118048 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Schematic representation of tcMEP and LDF recording. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 531-538DOI: (10.1067/mtc.2002.118048) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 tcMEP amplituded and relative LDF values during thoracic and lumbar SCI in one animal are shown. Downward vertical arrows indicate time points (22 and 109 minutes, respectively) at which flow values reached the desired thresholds (<25% for the ischemic spinal cord segment and >75% for the nonischemic spinal cord segment) to induce selective thoracic or lumbar SCI. Note gradual reduction of tcMEP amplitude after thoracic SCI compared with rapid tcMEP loss after lumbar SCI. Upward vertical arrows indicate time points (42 and 112 minutes, respectively) at which all arterial clamps were released. L5, Relative flow values at fifth lumbar vertebral level; Th10, relative flow values at 10th thoracic vertebral level. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 531-538DOI: (10.1067/mtc.2002.118048) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Individual values of laser-Doppler SCBF(ld_SCBF) and times until loss of lower-limb tcMEP signal during lumbar and thoracic SCI. Animals are ranked according to these times. In animals indicated by arrows, thoracic SCI was induced first, followed by lumbar SCI. Closed bars representing relative laser-Doppler SCBF values in the ischemic segment are superimposed on the open bars representing relative laser-Doppler SCBF values in the nonischemic segment. A and B, Animals in which target levels in ischemic segment during lumbar SCI were not reached. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 531-538DOI: (10.1067/mtc.2002.118048) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions