Danielle Posthuma, Michelle Luciano, Eco J. C. de Geus, Margie J

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Presentation transcript:

A Genomewide Scan for Intelligence Identifies Quantitative Trait Loci on 2q and 6p Danielle Posthuma, Michelle Luciano, Eco J. C. de Geus, Margie J. Wright, P. Eline Slagboom, Grant W. Montgomery, Dorret I. Boomsma, Nicholas G. Martin The American Journal of Human Genetics Volume 77, Issue 2, Pages 318-326 (August 2005) DOI: 10.1086/432647 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Full autosomal genome scans for PIQ, VIQ, and FSIQ based on 634 sibling pairs. Horizontal solid lines denote genomewide empirical thresholds for significant linkage, defined as the LOD score that would be expected to occur by chance with a probability of 0.05 in a whole-genome scan. Horizontal dashed lines denote genomewide empirical thresholds for suggestive linkage, defined as the LOD score that would be expected to occur once by chance in a whole-genome scan (Lander and Kruglyak 1995). The American Journal of Human Genetics 2005 77, 318-326DOI: (10.1086/432647) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 Genomic regions with suggestive or significant linkage in the Dutch (blue), Australian (green), and combined (red) data sets. Vertical dotted lines represent the positions of the markers. Horizontal solid red lines denote genomewide empirical thresholds in the combined data set for significant linkage, defined as the LOD score that would be expected to occur by chance with a probability of 0.05 in a whole-genome scan. Horizontal dashed red lines denote genomewide empirical thresholds in the combined data set for suggestive linkage, defined as the LOD score that would be expected to occur once by chance in a whole-genome scan (Lander and Kruglyak 1995). Information content, as a measure of entropy in the IBD distribution (Kruglyak et al. 1996), in the Dutch (black) and Australian (gray) data sets is plotted in the top panels. The American Journal of Human Genetics 2005 77, 318-326DOI: (10.1086/432647) Copyright © 2005 The American Society of Human Genetics Terms and Conditions