Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma Annett Linge, Ricarda Rauschenberg, Sophia Blum,

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Presentation transcript:

Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma Annett Linge, Ricarda Rauschenberg, Sophia Blum, Petra Spornraft-Ragaller, Friedegund Meier, Esther G.C. Troost Clinical and Translational Radiation Oncology Volume 15, Pages 42-45 (February 2019) DOI: 10.1016/j.ctro.2018.12.004 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Timeline showing the diagnoses, initiated therapies and detected relapses. Clinical and Translational Radiation Oncology 2019 15, 42-45DOI: (10.1016/j.ctro.2018.12.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 (A) Transverse view of a CT scan depicting the (FDG-PET-positive) mediastinal lymphadenopathy, which was proven tumour positive and referred for palliative irradiation in March 2016. (B) Radiation treatment plan encompassing the affected hilar and mediastinal lymph nodes (30 Gy total dose in 10 fractions of 3 Gy). The coloured lines represent the various isodose lines (see legend). (C) When the patient presented with shortness of breath (NYHA class II, CTCAE grade 2), the CT scan (lung setting) revealed ample radiological changes corresponding with a pneumonitis after irradiation, combined with immunotherapy and underlying HIV-infection as well as sarcoidosis (December 2016). (D) Complete remission of the mediastinal lymphadenopathy was diagnosed in March 2017. Clinical and Translational Radiation Oncology 2019 15, 42-45DOI: (10.1016/j.ctro.2018.12.004) Copyright © 2018 The Authors Terms and Conditions