Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality Marianne S. Nørskov, MSc, PhD, Morten Dahl, MD, DMSc, Anne Tybjærg-Hansen,

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Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality Marianne S. Nørskov, MSc, PhD, Morten Dahl, MD, DMSc, Anne Tybjærg-Hansen, MD, DMSc Journal of Thoracic Oncology Volume 12, Issue 11, Pages 1664-1672 (November 2017) DOI: 10.1016/j.jtho.2017.07.008 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Lung function according to glutathione S-transferase pi 1 gene (GSTP1) variants in the general population, overall and by smoking status. Data are presented as mean plus or minus SE. p Values were determined by test for trends. Numbers total slightly less than the number of all participants genotyped, as not all participants had spirometry performed. Ile105Val, amino acid isoleucine 105 changed to a valine; Ala114Val, amino acid alanine 114 changed to a valine; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity. Journal of Thoracic Oncology 2017 12, 1664-1672DOI: (10.1016/j.jtho.2017.07.008) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Cumulative incidences of lung cancer and tobacco-related cancer as a function of glutathione S-transferase pi 1 gene (GSTP1) variants, after adjustment for death as a competing event. p Values are for trend tests across subhazard ratios in Fine-Gray models. Ile, isoleucine; Ala, alanine. Journal of Thoracic Oncology 2017 12, 1664-1672DOI: (10.1016/j.jtho.2017.07.008) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Risk for development of lung cancer and tobacco-related cancer according to glutathione S-transferase pi 1 gene (GSTP1) variants in the general population. Hazard ratios were determined by Cox regression analysis. Multivariate adjusted models included age, sex, pack-years of smoking, and body mass index. p Values were determined by test for trends. Ile105Val, amino acid isoleucine 105 changed to a valine; Ala114Val, amino acid alanine 114 changed to a valine; CI, confidence interval. Journal of Thoracic Oncology 2017 12, 1664-1672DOI: (10.1016/j.jtho.2017.07.008) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 4 Cumulative incidence of all-cause mortality as a function of glutathione S-transferase pi 1 gene (GSTP1) variants. p Values were determined by test for trends. Abbreviations: Ile, isoleucine; Val, valine; Ala, alanine. Journal of Thoracic Oncology 2017 12, 1664-1672DOI: (10.1016/j.jtho.2017.07.008) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 5 Risk for all-cause mortality according to glutathione S-transferase pi 1 gene (GSTP1) variants in the general population, overall and by smoking status. Hazard ratios were determined by Cox regression analysis. Multivariate adjusted models included age, sex, pack-years of smoking, and body mass index. p Values were determined by test for trends. Ile105Val, amino acid isoleucine 105 changed to a valine; Ala114Val, amino acid alanine 114 changed to a valine; CI, confidence interval. Journal of Thoracic Oncology 2017 12, 1664-1672DOI: (10.1016/j.jtho.2017.07.008) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions