iRhoms: ERADicating the Messenger in Growth Control Signaling

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iRhoms: ERADicating the Messenger in Growth Control Signaling Stewart Siyan Cao, Randal J. Kaufman Developmental Cell Volume 20, Issue 4, Pages 414-416 (April 2011) DOI: 10.1016/j.devcel.2011.04.003 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 iRhoms Regulate EGF Secretion through ERAD The secretion of EGF family ligands is constitutively regulated by ER transmembrane pseudoproteases called iRhoms. (Top) After folding and post-translational modification in the ER, EGF can bind to iRhom on the ER membrane, which targets EGF to the ERAD machinery for degradation. This process requires the ERAD components EDEM2 and HRD1 and the 26S proteasome. (Bottom) Alternatively, EGF is packaged in COPII vesicles for trafficking to the Golgi apparatus, where it is cleaved by rhomboid proteases and released from the cell. Developmental Cell 2011 20, 414-416DOI: (10.1016/j.devcel.2011.04.003) Copyright © 2011 Elsevier Inc. Terms and Conditions