P.C. Pastoureau, E.B. Hunziker, J.-P. Pelletier

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Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis P.C. Pastoureau, E.B. Hunziker, J.-P. Pelletier Osteoarthritis and Cartilage Volume 18, Pages S106-S112 (October 2010) DOI: 10.1016/j.joca.2010.05.024 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Left operated proximal tibia of a MNX guinea pig. Site of measurement of histomorphometric parameters: medial tibial plateau (arrow). Safranin O staining. L=ligament. C=cavitation. GP=growth plate. (magnification: ×10)5. Osteoarthritis and Cartilage 2010 18, S106-S112DOI: (10.1016/j.joca.2010.05.024) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Left operated tibial plateau of a MNX guinea pig. Area of measurement of the CT (in μm): automatically generated between the two manually indicated points (one and two) at the margin of cartilage (C) and bone (B). Safranin O staining. (magnification: ×20)5. Osteoarthritis and Cartilage 2010 18, S106-S112DOI: (10.1016/j.joca.2010.05.024) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Left operated tibial plateau of a sham-operated (SH) and MNX guinea pig. Measurement of the FI; automatically calculated as follows: FI=(length of upper margin of cartilage (L)/width of area of measurement (W)) x100. Safranin O staining. (magnification: ×80)5. Osteoarthritis and Cartilage 2010 18, S106-S112DOI: (10.1016/j.joca.2010.05.024) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Left operated tibial plateau of a SH and MNX guinea pig. Automatic measurement of the SOI in the deep (D) and upper (U) zones of the articular cartilage after manual delimitation of the D from the U zones. PGs content ratio of the cartilage is expressed as SOI in U/SOI in D. Safranin O staining. (magnification: ×80)5. Osteoarthritis and Cartilage 2010 18, S106-S112DOI: (10.1016/j.joca.2010.05.024) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Left medial tibial plateau of a guinea pig. SBPT in μm was automatically measured after segmentation of bone in the half superior part of the epiphysis (dark area). Goldner trichrome staining. L = ligament, GP = growth-plate, BE=bone epiphysis. (magnification: ×12.5)5. Osteoarthritis and Cartilage 2010 18, S106-S112DOI: (10.1016/j.joca.2010.05.024) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions