S.M. Hosseini, M.B. Veldink, K. Ito, C.C. van Donkelaar

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Presentation transcript:

Is collagen fiber damage the cause of early softening in articular cartilage? S.M. Hosseini, M.B. Veldink, K. Ito, C.C. van Donkelaar Osteoarthritis and Cartilage Volume 21, Issue 1, Pages 136-143 (January 2013) DOI: 10.1016/j.joca.2012.09.002 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (a): Indenter displacement against time to monitor softening (control group, blue line) and to apply peak loads (increasing load group, red line) (Cartilage thickness 1 mm). (b): Typical relaxation curve during 10% indentation: peak value (black dot), equilibrium value (green line), and force reduction value (red arrow). Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Normalized peak values (mean + 95% confidence intervals). Reported P-values are those comparing the values of the 11 cycles within each loading protocol. n is the number of independent samples, and m is the number of femurs used to collect samples. Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Normalized equilibrium values (mean + 95% confidence intervals). Reported P-values are those comparing the values of the 11 cycles within each loading protocol. n is the number of independent samples, and m is the number of femurs used to collect samples. Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Bar graph with all FRP per experiment type displayed as subtraction of (a): the second from the first cycle value, b: the last from the first cycle value. (Mean ± 95% confidence intervals). Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Average compositional parameters per experiment type. GAG and collagen fractions are normalized to the dried weight of the sample. (Mean ± 95% confidence intervals). Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Typical histological sections from two samples per staining: (a, b): picrosirius red, (c, d): safranin O/fast green, (e, f): Col2-3/4M, (g, h): Col2-3/4Cshort, (i): Col2-3/4M positive control. Left: from 6 N experiments, right: from 15 N experiments. Osteoarthritis and Cartilage 2013 21, 136-143DOI: (10.1016/j.joca.2012.09.002) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions