Fig. 1. Blood exosomal miRNA changes in patients with SCZ

Slides:

Advertisements

Similar presentations

(A) Western ... (A) Western blot showing DTX1 knockdown with siRNA in human CD4+ T cells. Actin was used as the loading control. (B) Purified.

Advertisements

Figure 1. Bar plots of age-standardized (world population) death rates per 100 000 persons for the year 2014 (blue, ... Figure 1. Bar plots of age-standardized.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Fig. 1. (a) The 10-fold cross validation result of random forest model using an independent population (Austria, ... Fig. 1. (a) The 10-fold cross validation.

Figure 4 ROMs have a morph-specific effect relative to active aggression but not display behavior in dominant males. ... Figure 4 ROMs have a morph-specific.

Fig. 1. Social cognition, language, and social behavior of children at familial high-risk of schizophrenia or bipolar ... Fig. 1. Social cognition, language,

Figure 1 Data-selection process

Figure 1 Flow diagram detailing the systematic review process.

Fig. 1. Axial, coronal, and sagittal views of post hoc results (mean gFA) demonstrating significant differences ... Fig. 1. Axial, coronal, and sagittal.

Figure 1 Mechanism of mortality benefit associated with radial access

(A) mSchober in DESIR; (B) mSchober in SPACE; (C) LSF ...

Figure 1. Linkage analyses of the SNPs in the MRE11 gene and haplotype blocks. Haplotype blocks were defined for all ... Figure 1. Linkage analyses of.

(A–B) Images of US ... (A–B) Images of US assessment of both patients who developed peripheral arthritis during vedolizumab treatment undergoing US-guided.

Fig. 1 Bone scintigraphy of the right tibia of the patient at disease onset (A), after 10 years of calcitonin ... Fig. 1 Bone scintigraphy of the right.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Figure 1 The Kaplan–Meier curves of time to death post first hospitalization. hosp, hospitalization. Unless provided in the caption above, the following.

AHA: American Heart Association; ALT: ...

Figure 1. Serum ceftazidime concentrations following intravenous administration. Unless provided in the caption above, the following copyright applies.

Figure 1 A dot plot illustrating the correlation between the yearly absolute risk difference for both MACE and major ... Figure 1 A dot plot illustrating.

Fig. 1 CT demonstrating aortic wall thickening with renal artery involvement (short arrow). There is also subtle ... Fig. 1 CT demonstrating aortic wall.

Figure 1. SpeI-PFGE dendrogram comparing P

Source: Figure created by the author based on data ...

bDMARD: biologic DMARD.

Black: diagnosis ... Black: diagnosis from any department; grey: diagnosis at a rheumatology department. Unless provided in the caption above, the following.

(A) The 10 most commonly involved organs in female and male ...

Fig. 1 Graphical representation of improving mortality in stroke patients since the inception of a national stroke ... “Graph courtesy of George Dunn,

Fig. 1 MRI aspect of an osteitis of the left acetabulum at baseline (A), 3 months (B), 1 year (C) and 2 years later, ... Fig. 1 MRI aspect of an osteitis.

Figure 1. Historical dialectic framework to assess transnational advocacy network influence Unless provided in the caption above, the following copyright.

Take home figure The protective role of CNP/NPR-B/NPRC.

Fig. 3 Interrelationship between themes describing the experiences of people with shoulder disorders Unless provided in the caption above, the following.

A. PMPs; B. endotheliocyte-derived MPs; C. leukocyte-derived MPs

x-axis, post-partum days. Closed ...

Fig. 1. A flowchart of cohort participants screened, enrolled and followed-up between 1 July 2015 and 31 May Fig. 1. A flowchart of cohort participants.

Fig. 1 Subacute cutaneous lupus erythematous at the lower limbs

Fig. 1 Flow chart of included patients for analyses

Fig. 1 Flow chart for selection of study subjects

Figure 1 Plot showing the interaction between Indigenous group belonging and use of family health centres Figure 1 Plot showing the interaction between.

Increased ... Increased brain connectivity between the SMN and left insula (A), DMN and right middle frontal gyrus (B) and DAN and bilateral medial prefrontal.

Figure 1. Profiles of the top 50 mRNA probes of the first gene signature identified in the South African cohort. ... Figure 1. Profiles of the top 50 mRNA.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Figure 1 Relationships between pair indices of dance performance (joint entropy or mutual information) and the past ... Figure 1 Relationships between.

(A, B) Representative TEM images from the skin ...

Figure 1. Flow diagram for selection of articles for systematic review. Unless provided in the caption above, the following copyright applies to the content.

Figure 1. Time–kill studies for selected isolates (each line represents the average of duplicate studies). AMP, ... Figure 1. Time–kill studies for selected.

Figure 1 Immunohistochemistry for human cell differentiation molecules in samples of the right ventricular septum from ... Figure 1 Immunohistochemistry.

Figure 1. Percentage of Pacific and European children completing all components of B4SC in 2013 and 2015 Figure 1. Percentage of Pacific and European.

Fig. 1. Timing of the functional magnetic resonance imaging (fMRI) evidence integration task. Participants were ... Fig. 1. Timing of the functional magnetic.

Figure 1. Trunk and leg fat over study period. LS, log transformed.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Fig. 1 Kaplan-Meier plot presenting no difference in progression to RA in patients with clinically suspect ... Fig. 1 Kaplan-Meier plot presenting no difference.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Figure 2. Biomarkers for prediction of differences in PFS and objective response rate between GP and GT arm in patients ... Figure 2. Biomarkers for prediction.

Fig. 1. The ZNF804A interactome

Fig. 1 A network representation of top 100 co-occurring terms

Fig. 1 Statistics of the main characters’ dialogues.

Fig. 1 Query formulation process in CLIR

Figure 1 Grant agencies and charitable foundations supporting Plan S.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Fig. 1 Schematic subcategorization of AAV in three clinically relevant disease categories defined by clinical ... Fig. 1 Schematic subcategorization of.

Fig. 1: World distribution of field sampling locations of Aedes aegypti and Aedes mascarensis screened for Wolbachia ... Fig. 1: World distribution of.

Fig. 2. Default mode network (DMN) patterns in each of the 3 groups and longitudinal changes after treatment. (A–C) ... Fig. 2. Default mode network (DMN)

Figure 1 Strategies for reconciling protection and participation.

(A) Western ... (A) Western blot showing DTX1 knockdown with siRNA in human CD4+ T cells. Actin was used as the loading control. (B) Purified.

Figure 1. Kaplan Meier curves showing crude product limit survival estimates and 95% confidence intervals for time to ... Figure 1. Kaplan Meier curves.

Figure 1. Measuring respondent unhappiness with their child marrying someone from the other party and happiness with ... Figure 1. Measuring respondent.

Figure 1 ABCDE of primary prevention.2

Figure 1. Forest plot of lung cancer mortality in LDCT trials.

Table 2. Mean noise level results for hand dryers in dBA

Presentation transcript:

Fig. 1. Blood exosomal miRNA changes in patients with SCZ Fig. 1. Blood exosomal miRNA changes in patients with SCZ. (A) Serum exosome observation by electron microscopy and ... Fig. 1. Blood exosomal miRNA changes in patients with SCZ. (A) Serum exosome observation by electron microscopy and ×7000 magnification. (B) Western blots show the exosomal marker Alix and Flotillin-1 were present in the exosomes extracted from blood. (C) Western blots show that endoplasmic reticulum marker CNX and Golgi marker GP-73 were not present in the peripheral blood exosomes. (D) Serum exosome validation by nanoparticle tracking device—ZetaView. Note that the particles peak around at 100 nm. (E) MA-plot displaying miRNA differences between cases and controls for the training set of participants. (F) MA-plot for the testing set of participants. (G) MA-plot for pooled set of participants. (H) Significantly changed blood exosomal miRNA expression in the 49 cases as compared with 46 controls. CNX, Calnexin; GP-73, Golgi protein-73. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Schizophr Bull, sby191, https://doi.org/10.1093/schbul/sby191 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 2. Blood exosomal miRNAs as biomarkers to differentiate between SCZ patients and controls. (A) ROC curves were ... Fig. 2. Blood exosomal miRNAs as biomarkers to differentiate between SCZ patients and controls. (A) ROC curves were utilized to evaluate the accuracy of a cluster of 11 miRNAs for the diagnosis of SCZ in a training set of participants. Boxplot (B) and scatter plot (C) of probability of participants belonging to cases by the 11 miRNAs in the training set. (D) ROC curves were utilized to evaluate the accuracy of a cluster of 11 miRNAs for the diagnosis of SCZ in a testing set of participants. Boxplot (E) and scatter plot (F) of probability of participants belonging to case in the testing set. AUC, area under curve; ROC, receiver operating characteristic. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Schizophr Bull, sby191, https://doi.org/10.1093/schbul/sby191 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 3. miRNA coexpression modules dysregulated in blood exosomes of SCZ patients. (A) Dendrogram showing miRNA ... Fig. 3. miRNA coexpression modules dysregulated in blood exosomes of SCZ patients. (A) Dendrogram showing miRNA coexpression modules defined in 95 samples. Color bars indicate dynamic module assignments (Dynamic Tree Cut) and merged module assignments (Merged dynamic). (B) Pearson’s correlation coefficient (and P value in parentheses) between disease status, age, gender, disease severity, and module eigengene. (C) Log2 transformed fold change distribution of miRNAs in the module black, blue, brown, green greenyellow, purple, turquoise, and yellow. (D–F) Coexpression network plots for greenyellow, black, and yellow modules. Node size is proportional to node connectivity, and edge indicates coexpression of connected nodes with intramodular connectivity >0.5. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Schizophr Bull, sby191, https://doi.org/10.1093/schbul/sby191 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 4. Quantitative reverse transcription-polymerase chain reaction validation of differentially expressed miRNAs in ... Fig. 4. Quantitative reverse transcription-polymerase chain reaction validation of differentially expressed miRNAs in the blood exosomes of SCZ patients. hsa-miR-206 (A), hsa-miR-144-3p (C), and hsa-miR-619-5p (E) expression in the blood exosomes of 100 cases and 100 controls. hsa-miR-206 (B), hsa-miR-144-3p (D), and hsa-miR-619-5p (F) in the blood exosomes of 57 FEDF SCZ patients, 43 CT SCZ patients, and 100 controls. FEDF, first-episode, drug-free; CT, chronically treated. **P < .01, ***P < .001. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Schizophr Bull, sby191, https://doi.org/10.1093/schbul/sby191 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 5. Validation of bioinformatic prediction of miRNA target genes Fig. 5. Validation of bioinformatic prediction of miRNA target genes. (A) Whole-blood BDNF mRNA levels between 45 ... Fig. 5. Validation of bioinformatic prediction of miRNA target genes. (A) Whole-blood BDNF mRNA levels between 45 FEDF SCZ patients and 45 controls. (B) Serum BDNF protein levels between 53 FEDF SCZ patients, 51 CT SCZ patients, and 47 controls. (C) KEGG pathway enrichment result for the SCZ-affected upregulated yellowgreen module. (D) GALNT8, (E) GLANT15, and (F) GLANT18 whole-blood mRNA levels between 45 FEDF SCZ patients and 45 controls. CT, chronically treated; FEDF, first-episode, drug-free. *P < .05, ***P < .001. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Schizophr Bull, sby191, https://doi.org/10.1093/schbul/sby191 The content of this slide may be subject to copyright: please see the slide notes for details.