Complex Role of TNF Variants in Psoriatic Arthritis and Treatment Response to Anti- TNF Therapy: Evidence and Concepts Ulrike Hüffmeier, Rotraut Mössner

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Complex Role of TNF Variants in Psoriatic Arthritis and Treatment Response to Anti- TNF Therapy: Evidence and Concepts Ulrike Hüffmeier, Rotraut Mössner Journal of Investigative Dermatology Volume 134, Issue 10, Pages 2483-2485 (October 2014) DOI: 10.1038/jid.2014.294 Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Upper part: Genomic arrangement of genes on chromosome 6p21.3. Thicker sections of the horizontal line represent the genes for coiled-coil helical rod protein 1 (CCHCR1), HLA-C, and tumor necrosis factor (TNF). Large solid boxes represent exons, and small solid boxes represent the 3′-untranslated region (3′-UTR) or 5′-UTR. Arrowheads represent the orientation of the genes. Vertical bars indicate 7 of the 8 relevant single-nucleotide polymorphisms (SNPs), which are located at CCHCR1 (n=2), and TNF promoter and first intron (n=5). Arrows in the middle part indicate correlations of relative positions of SNPs between the upper and lower parts of the figure. Lower part: Linkage disequilibrium (LD) structure of the PSORS1 risk haplotype as defined by Huffmeier et al. (2009) and of selected SNPs at the TNF locus in 226 PsA patients analyzed as described previously (Reich et al., 2007). Genotypes of intronic variant at +489 were determined in a genome-wide association study published previously (Huffmeier et al., 2010). (a) Physical relationship of variants, (b) name of selected variants, and (c) pairwise LD plot of the PSORS1 risk haplotype and selected SNPs (illustrated by Haploview (Barrett et al., 2005). Each square plots the level of LD between a pair of sites in the region; comparisons between neighboring sites lie along the first line. Black color indicates strong LD, gray indicates intermediate or uninformative LD, and white indicates weak LD. The black triangle indicates neighboring SNPs within an LD block. Journal of Investigative Dermatology 2014 134, 2483-2485DOI: (10.1038/jid.2014.294) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions