Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

Slides:



Advertisements
Similar presentations
Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.
Advertisements

Role of TNF in fracture healing in vivo Addition of rhTNF at the fracture site on days 0 and 1 led to augmented healing, indicated by increased % callus.
Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based.
Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.
Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.
Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.
Reduced scar formation in the injured GM of CCR2−/− mice
Amyloid‐associated gliosis in APPPS1‐21 transgenic mice.
Dual anti‐Ang‐2 and anti‐VEGF therapy acts synergistic on vascular normalization and macrophage infiltration in experimental GBM Dual anti‐Ang‐2 and anti‐VEGF.
Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.
The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.
IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.
[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.
TFE3 regulates glucose homeostasis
Metabolic profile of Tfe3 KO mice
TGF‐β1 and Sema3A are downregulated in vivo by increasing VEGF doses Muscles were harvested 7 days after implantation of V Low, V Med, and V High clones.
Impaired fear extinction precedes memory decline in Fmn2 mutant mice
No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.
Effects of GM1 on astroglial and microglial markers
Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),
TFE3 prevents diet‐induced obesity and metabolic syndrome
EGFL7 affected tumor growth and reduced overall survival
Expression of PD‐1 on PBMC and malignant exudate T cells
Validation of astrocyte and microglial proteomic markers that increase across the ALS‐FTD spectrum Validation of astrocyte and microglial proteomic markers.
Combination of OTX‐015 and PD does not induce overt toxicity
Stat3C/C mice are more prone to Th17 differentiation. A
PERK activator treatment protects neurite network
WT‐HSCT, LV. IDS, and LV. IDS
Molecular and morphological analysis of Pitrm1+/− mouse brain
Intra‐eWAT administration of FGF21 vectors in ob/ob mice
Nec‐1 inhibits the phosphorylation and aggregation of tau
High frequency and unique tumor‐initiating cells (TICs) in Pten/p53‐deficient mice Flow cytometry profiles of indicated tumors with the CD24 and CD49f.
Hdac3 deletion decreases AKT phosphorylation and tumor growth in Pten knockout prostate cancer Hdac3 deletion decreases AKT phosphorylation and tumor growth.
Rescuing mGPDH deficiency improves skeletal muscle regeneration during obesity and diabetes Rescuing mGPDH deficiency improves skeletal muscle regeneration.
Anti‐EGFL7 treatment for the treatment of glioma in vivo
EGFL7 promoted density and maturation state of glioma vessels
VAP silencing restores a normal plasma membrane cholesterol level in STARD3‐expressing cells VAP silencing restores a normal plasma membrane cholesterol.
Normal priming and expansion of functional T cells in the spleen during concurrent co‐infection Normal priming and expansion of functional T cells in the.
IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.
Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages.
LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.
High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation High‐fat diet augments gut permeability, metabolic endotoxemia,
TGFβ signaling activity in smooth muscle cells in human left main coronary arteries with various degrees of atherosclerosis TGFβ signaling activity in.
Endothelial Ang‐2 upregulation correlates with WHO grading in human gliomas Endothelial Ang‐2 upregulation correlates with WHO grading in human gliomas.
EnAd‐EpCAMBiTE shows reproducible activity within an expanded cohort of patient malignant peritoneal and pleural exudates EnAd‐EpCAMBiTE shows reproducible.
Enhancement of receptor endocytosis, as well as cellular apoptosis, may explain the cooperative anti‐tumor actions of 3×mAbs and osimertinib Enhancement.
Target engagement of the systemic Stat3 inhibitor in APP/PS1 mice
EGFL7 increased surface expression of integrins α5β1 and αVβ3
Validation of astrocyte and microglial proteomic markers that increase across the ALS‐FTD spectrum Validation of astrocyte and microglial proteomic markers.
Absence of a vestibular phenotype in CIB2−/− mice
I.c.v.‐injected AβOs induce increased food intake, hypothalamic expression of orexigenic neuropeptides but no hypothalamic cell degeneration AAccumulated.
MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.
Volume 21, Issue 4, Pages (April 2013)
Rescue of motor neurons from death The ventral root of the fifth lumbar segment (L5). Rescue of motor neurons from death The ventral root of the fifth.
Microglial P2X4R modulates oligodendrocyte differentiation
Absence of a retinal phenotype in CIB2−/− mice
Treatment with AZD5363 reduces the proportion of proliferating vascular endothelial cells and following RT, the influx of CD11b+ bone marrow‐derived cells.
Etifoxine modulation of T‐cell activity during EAE
Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,
Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts.
PKAN human neurons show altered oxidative status
Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.
Sox2 is essential for SLG regeneration following radiation injury
Catalytic activity of mTERT is needed for increased healthspan and life‐span extension in AAV9‐mTERT treated mice.A.Scheme of mTERT‐wt and mTERT‐DN, a.
GM1 decreases neuropathology and weight loss in R6/2 mice
Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids.
Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.
Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.
Brain ischemic tolerance model using mouse MCAO
Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.
Presentation transcript:

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice A–DCytokine bead arrays measuring (A) MIP‐1α, (B) IL‐1α, (C) RANTES, and (D) MCP‐1 levels in whole‐brain lysate of 8‐month‐old mice using flow cytometry (n = 6 mice/group).ERepresentative images of 30‐μm sections of the motor cortex (M2) and striatum stained with isolectin B4 (ILB4) to identify activated microglia, 40×. Scale bar: 50 μm.F, GFour 30‐μm sections per mouse of the cortex (F) and striatum (G) were counted for the number of ILB4‐positive cells (0.26 to −1.94 mm from bregma), n = 3 mice/group.HSchematic of the Y‐maze to measure working memory.IPercentage alternation as an indicator of working memory was measured in 10‐min trials in the Y‐maze at 8 months of age. n = 12–16 mice per group.Data information: Data are mean ± SEM, one‐way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. MPS II; other comparisons are indicated by brackets. Hélène FE Gleitz et al. EMBO Mol Med. 2018;10:e8730 © as stated in the article, figure or figure legend