Fig. 4. Actin polymerization rhythms are required for circadian regulation of adhesion and wound-healing efficacy by fibroblasts. Actin polymerization.

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Fig. 4. Actin polymerization rhythms are required for circadian regulation of adhesion and wound-healing efficacy by fibroblasts. Actin polymerization rhythms are required for circadian regulation of adhesion and wound-healing efficacy by fibroblasts. (A) Impedance measurements from cry1−/− cry2−/− (blue) or wild-type fibroblasts treated with DMSO (black) or cytoD (orange) with simultaneous PER2::LUC measurements (heat maps) (n = 6 to 8; mean ± SEM). AU, arbitrary unit. (B) Quantification of mean fibroblast monolayer healing after wounding at the indicated times after synchronization (t) in the presence of 0.5 μM cytoD or vehicle (n = 6 to 12; mean ± SEM). P values from an ANOVA with Tukey’s test for multiple comparisons are indicated. Nathaniel P. Hoyle et al., Sci Transl Med 2017;9:eaal2774 Published by AAAS