Adnan M. Al-Ayoubi, MD, Jonathan S. Ralston, MD, S

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Diffuse Pulmonary Neuroendocrine Cell Hyperplasia Involving the Chest Wall Adnan M. Al-Ayoubi, MD, Jonathan S. Ralston, MD, S. Russ Richardson, BS, Chadrick E. Denlinger, MD The Annals of Thoracic Surgery Volume 97, Issue 1, Pages 333-335 (January 2014) DOI: 10.1016/j.athoracsur.2013.04.139 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Noncontrast chest computed tomographic image demonstrating a solitary, spiculated, noncalcified nodule in the base of the right lower lobe (arrow). The Annals of Thoracic Surgery 2014 97, 333-335DOI: (10.1016/j.athoracsur.2013.04.139) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Histopathologic specimens with routine hematoxylin and eosin staining of surgical specimens. (A) Biopsy specimen of the parietal pleura demonstrating insular nest of tumor cells with abundant pale eosinophilic cytoplasm and bland nuclei. Immunohistochemical stains for chromogranin, synaptophysin, and Thyroid transcription factor -1 (TTF-1) were positive (not shown) (original magnification, X200). (B) Representative section from the primary lung tumor showing invasive adenocarcinoma. Infiltrative, irregular glands with atypical nuclei and scattered mitoses within desmoplastic stroma. Immunohistochemical stains for cytokeratin 7 and TTF-1 were positive, whereas chromogranin and synaptophysin were negative (not shown) (original magnification, X200). (C) Carcinoid tumorlets from lung parenchyma adjacent to primary lung adenocarcinoma. Neuroendocrine cells with increased nuclear to cytoplasmic ratios, stippled chromatin, and inconspicuous nucleoli are seen around small bronchioles (original magnification, X400). The Annals of Thoracic Surgery 2014 97, 333-335DOI: (10.1016/j.athoracsur.2013.04.139) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions