Three-dimensional summary images of results from shape analysis of hippocampus, caudate, putamen and globus pallidus from superior and inferior views,

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Three-dimensional summary images of results from shape analysis of hippocampus, caudate, putamen and globus pallidus from superior and inferior views, showing association between plasma glucose levels and shape differences among participants with normal fas... Three-dimensional summary images of results from shape analysis of hippocampus, caudate, putamen and globus pallidus from superior and inferior views, showing association between plasma glucose levels and shape differences among participants with normal fasting plasma glucose levels (NFG) (top rows) and with type 2 diabetes (T2D) (middle rows). Bottom rows show shape differences between participants with T2D and participants with NFG (diabetes vs NFG). The color bar indicates the t statistic values presented on the surface maps. Results are statistically significant (p<0.05) at t<−1.96 for inward deformation and t>1.96 for outward deformation associated with plasma glucose levels or classification of T2D. Results were adjusted for all covariates. Structures with significant (p<0.05) volumetric differences indicating smaller volume are marked with blue squares, while those with volumetric differences indicating greater volume are marked with red squares. Tianqi Zhang et al. BMJ Open Diab Res Care 2016;4:e000175 ©2016 by American Diabetes Association