Synaptic Vesicle Distribution by Conveyor Belt

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Synaptic Vesicle Distribution by Conveyor Belt Armen J. Moughamian, Erika L.F. Holzbaur Cell Volume 148, Issue 5, Pages 849-851 (March 2012) DOI: 10.1016/j.cell.2012.02.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 “Conveyor Belt” Model for the Equal Distribution of Dense Core Vesicles in Synapses The probability of capture of a dense core vesicle in any particular synapse is low. However, the microtubule motors, kinesin and dynein/dynactin, drive the continuous circulation of dense core vesicles in the axon, ultimately yielding an equal distribution of vesicles among synapses. This model is analogous to people at a conveyor belt sushi restaurant, where each plate of sushi is a dense core vesicle and the patrons are synapses. As the sushi travels around the conveyor belt, patrons take what they want while allowing many of the plates to pass. Ultimately, all of the patrons are equally satiated. Unlike a conventional conveyor belt, vesicle circulation relies on a switch in the driving motor at opposite ends of the circuit. Cell 2012 148, 849-851DOI: (10.1016/j.cell.2012.02.007) Copyright © 2012 Elsevier Inc. Terms and Conditions