Directly Observing Therapy: A New View of Drug Tolerance in Tuberculosis  Jennifer A. Philips, Joel D. Ernst  Cell  Volume 145, Issue 1, Pages 13-14 (April 2011) DOI: 10.1016/j.cell.2011.02.041 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Antibiotic Tolerance in Replicating Mycobacteria Mediated by Macrophage-Induced Drug Efflux (A) Extracellular mycobacteria are killed and eliminated by antibiotics. (B) Mycobacteria that enter macrophages may retain susceptibility to drugs and be killed, or they may induce expression of efflux pumps, which makes them drug tolerant and able to replicate and persist in the face of otherwise lethal concentrations of antibiotics. Dashed arrows indicate potential fates of mycobacteria; solid arrows indicate the direction of drug accumulation in individual bacteria. Cell 2011 145, 13-14DOI: (10.1016/j.cell.2011.02.041) Copyright © 2011 Elsevier Inc. Terms and Conditions