NFATc2-deficient mice do not eliminate skin C. albicans infections.

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NFATc2-deficient mice do not eliminate skin C. albicans infections. NFATc2-deficient mice do not eliminate skin C. albicans infections. (A) Lesions in WT and NFATc2-deficient mice at the indicated time points after C. albicans hyphae injection in the deep derma. WT animals (top) undergo ulceration and C. albicans elimination, whereas NFATc2-deficient mice (bottom) develop a persistent abscess. (B) Kaplan-Meier curve showing the percentage of WT and NFATc2-deficient mice undergoing ulceration after C. albicans administration at the indicated time points; n = 10; log-rank test. Results are representative of at least six independent experiments. (C) Hematoxylin and eosin staining of WT (top) and NFATc2-deficient (bottom) mouse skin lesions at the indicated time points after C. albicans infections. Larger magnification of selected areas of the same section are shown to evidence granulocyte recruitment (left). PicroSirius Red staining is also shown to evidence collagen depositions (right, red deposits) and periodic acid–Schiff (PAS) staining to evidence Candida. See also fig. S2 for higher magnifications. Representative histological sections of four independent experiments are shown; see also fig. S3 (A and B). (D) WT and RAG-2–deficient mice respond similarly to primary skin infections with C. albicans. The Kaplan-Meier curve shows the percentage of WT and RAG-2–deficient mice undergoing ulceration after C. albicans administration at the indicated time points; n = 18 per group. (E) Digital image analysis quantification of collagen staining. Five fields from two sections (24 hours after infection) of two independent experiments were analyzed. The analyzed fields covered the entire sections excluding the skin. Means and SEM are depicted. n = 5; statistical significance, two-tailed t test. William Santus et al. Sci. Immunol. 2017;2:eaan2725 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works