Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful? Ting Seng Tang, MBBS, Thomas.

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Presentation transcript:

Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful? Ting Seng Tang, MBBS, Thomas Bieber, PhD, Hywel C. Williams, DSc Journal of Allergy and Clinical Immunology Volume 133, Issue 6, Pages 1615-1625.e1 (June 2014) DOI: 10.1016/j.jaci.2013.12.1079 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Putative diagram (top) illustrating what might currently happen when the initial induction of remission treatment period (started at point A) ceases once signs and symptoms have reduced (clinical remission or point B) as opposed to what might happen (bottom) if initial induction of remission extended to clear subclinical disease (subclinical remission or point C). Each induction of remission period is followed by maintenance or proactive treatment, requiring 2 consecutive days of treatment per week to previously active sites (points D). Journal of Allergy and Clinical Immunology 2014 133, 1615-1625.e1DOI: (10.1016/j.jaci.2013.12.1079) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2014 133, 1615-1625.e1DOI: (10.1016/j.jaci.2013.12.1079) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2014 133, 1615-1625.e1DOI: (10.1016/j.jaci.2013.12.1079) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2014 133, 1615-1625.e1DOI: (10.1016/j.jaci.2013.12.1079) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions