D. Ebel, P. Lipfert, J. FraÕßdorf, B. Preckel, J. MuÕllenheim, V

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Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart D. Ebel, P. Lipfert, J. FraÕßdorf, B. Preckel, J. MuÕllenheim, V. ThaÕmer, W. Schlack British Journal of Anaesthesia Volume 86, Issue 6, Pages 846-852 (June 2001) DOI: 10.1093/bja/86.6.846 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Experimental protocol. British Journal of Anaesthesia 2001 86, 846-852DOI: (10.1093/bja/86.6.846) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Left ventricular developed pressure (LVDP, top), left ventricular end-diastolic pressure (LVEDP, middle), and myocardial oxygen consumption (bottom) in the five groups. Low-flow ischaemia led to a marked reduction in LVDP and an increase in LVEDP. During reperfusion, LVDP recovered more in the groups that received lidocaine during ischaemia and early reperfusion. In these groups, myocardial oxygen consumption was also higher during reperfusion than in the control group. Data are mean (sem). *P<0.05, †P<0.01, ‡P<0.001 vs control. n=11 in each group. British Journal of Anaesthesia 2001 86, 846-852DOI: (10.1093/bja/86.6.846) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Cumulative creatine kinase release in the five groups. Lidocaine administered during ischaemia and early reperfusion reduced creatine kinase release. Lidocaine administration during reperfusion only had no effect on this marker of cellular damage. Data are mean (sem). *P=0.042, ‡P=0.001 vs control. n=10 in control group; n=11 in all other groups. British Journal of Anaesthesia 2001 86, 846-852DOI: (10.1093/bja/86.6.846) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions