Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with.

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Presentation transcript:

Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non–small cell lung cancer: Results from Cancer and Leukemia Group B 159902 Alice M. Boylan, MD, Xiaofei F. Wang, PhD, Richard Ko, DO, Patricia M. Watson, PhD, Lin Gu, MS, David Harpole, MD, Raphael Bueno, MD, Rosemary Kelly, MD, Leslie Kohman, MD, Robert Kratzke, MD The Journal of Thoracic and Cardiovascular Surgery Volume 146, Issue 1, Pages 206-211 (July 2013) DOI: 10.1016/j.jtcvs.2012.08.059 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Reverse transcriptase polymerase chain reaction (RT-PCR) analysis of human telomerase reverse transcriptase (hTERT) expression in lavage specimens. The messenger RNA levels of hTERT were determined by using RT-PCR. Fragments were resolved on 2% agarose gels and visualized by ethidium bromide staining. Lane 1 shows expression in the positive control, a lung adenocarcinoma cell line, and lane 2 shows the negative control, normal pleural mesothelial cells. Lanes 4-7 contain pleural lavage specimens. MW, Molecular weight markers. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 206-211DOI: (10.1016/j.jtcvs.2012.08.059) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Kaplan-Meier curves of (A) disease-free survival and (B) overall survival by telomerase activity. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 206-211DOI: (10.1016/j.jtcvs.2012.08.059) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions