G. E. Kuhnle, C. Hornuss, M. Lenk, A. P. Salam, D. Wiepcke, V

Slides:

Advertisements

Similar presentations

P.A. Bothma, C.J. Schlimp British Journal of Anaesthesia

Advertisements

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

Sevoflurane therapy for life-threatening asthma in children

Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems N Sigmond,

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane R.I. Westphalen,

M. M. Sahinovic, D. J. Eleveld, T Miyabe-Nishiwaki, M. M. R. F

Standardized deceased donor kidney donation rates in the UK reveal marked regional variation and highlight the potential for increasing kidney donation:

M. Daunderer, M. S. Feuerecker, B. Scheller, N. B. Pape, D

Characteristics of pain in hospitalized medical patients, surgical patients, and outpatients attending a pain management centre M.P. Rockett, G. Simpson,

Upper limb muscular activity and perceived workload during laryngoscopy: comparison of Glidescope® and Macintosh laryngoscopy in manikin: an observational.

Changes in sevoflurane plasma concentration with delivery through the oxygenator during on-pump cardiac surgery R. Nitzschke, J. Wilgusch, J.F. Kersten,

A.R. Absalom, V. Mani, T. De Smet, M.M.R. F. Struys

A different use of visual analytic techniques in anaesthetics

E.J. Bartley, R.B. Fillingim British Journal of Anaesthesia

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

S. Kreuer, J. Bruhn, R. Larsen, M. Hoepstein, W. Wilhelm

Comparison of oxygen uptake during arm or leg cardiopulmonary exercise testing in vascular surgery patients and control subjects L. Loughney, M. West,

B.M.Q. Weaver, G.E. Staddon, W.W. Mapleson

Bispectral index, serum drug concentrations and emergence associated with individually adjusted target-controlled infusions of remifentanil and propofol.

Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children C. Jeleazcov, H. Ihmsen,

Inflating LMA with normal saline: 14 yr after

Stroke volume variation and indexed stroke volume measured using bioreactance predict fluid responsiveness in postoperative children† E. Vergnaud, C.

T Emerick, D Metro, R Patel, T Sakai British Journal of Anaesthesia

A. Absalom, D. Amutike, A. Lal, M. White, G.N.C. Kenny

Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index† F.R.

Transpulmonary thermodilution cardiac output measurement is not affected by severe pulmonary oedema: a newborn animal study A Nusmeier, S Vrancken, W.P.

Changes in the rapidly extracted auditory evoked potentials index and the bispectral index during sedation induced by propofol or midazolam under epidural.

B. Allaouchiche, F. Duflo, J.-P. Tournadre, R. Debon, D. Chassard

Influence of nociceptive stimulation on analgesia nociception index (ANI) during propofol–remifentanil anaesthesia M. Gruenewald, C. Ilies, J. Herz,

Saliva cyclic GMP increases during anaesthesia

Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients Margarson M.P. , Soni N.C.

Bispectral index is related to the spread of spinal sensory block in patients with combined spinal and general anaesthesia R Iida, K Iwasaki, J Kato,

Continuous perineural infusion after lower extremity osteotomies in children: a feasibility and safety analysis W. Muhly, H. Gurnaney, H. Hosalkar, F.

Distraction and interruption in anaesthetic practice

Predictive performance of the modified Marsh and Schnider models for propofol in underweight patients undergoing general anaesthesia using target-controlled.

Nervus medianus evoked potentials and bispectral index during repeated transitions from consciousness to unconsciousness† I. Rundshagen, J. Mast, N.

Do old pharmacokinetic parameter estimates predict new data?

Heart-fatty acid-binding and tau proteins relate to brain injury severity and long-term outcome in subarachnoid haemorrhage patients E.R. Zanier, T Zoerle,

Chronic pain in adults after thoracotomy in childhood or youth

O. Tirel, E. Wodey, R. Harris, J.Y. Bansard, C. Ecoffey, L. Senhadji

C. Price, J. Lee, A.M. Taylor, A.P. Baranowski

Integration of academic and clinical performance-based faculty compensation plans: a system and its impact on an anaesthesiology department†‡ T Sakai,

II. Should anaesthetists stop infusing isotonic saline?

Effect of sevoflurane/nitrous oxide versus propofol anaesthesia on somatosensory evoked potential monitoring of the spinal cord during surgery to correct.

Validation of a measurement tool for self-assessment of teamwork in intensive care J Weller, B Shulruf, J Torrie, R Frengley, M Boyd, A Paul, B Yee, P.

Z Mokini, C Buccino, G Vitale, T Mauri, R Fumagalli, A Pesenti

Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in gynaecological patients with CO2 pneumoperitoneum stimulus Z.-Y.

Effects of halothane, sevoflurane and propofol on left ventricular diastolic function in humans during spontaneous and mechanical ventilation† Filipovic.

I. Wenningmann, S. Paprotny, S. Strassmann, R. K. Ellerkmann, B

Propofol for adult procedural sedation in a UK emergency department: safety profile in 1008 cases B Newstead, S Bradburn, A Appelboam, A Reuben, A Harris,

Single-cuff forearm tourniquet in intravenous regional anaesthesia results in less pain and fewer sedation requirements than upper arm tourniquet† F.B.

Effects of increasing sevoflurane MAC levels on mid-latency auditory evoked potentials in infants, schoolchildren, and the elderly M. Feuerecker, M.

J Lee, S Gupta, C Price, A.P. Baranowski

Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society J. Lee, B. Ellis, C. Price, A.P. Baranowski

Postoperative analgesic effect of intravenous (i. v

Cross-tolerance between spinal neostigmine and morphine in the rat

Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials F. Bilotta, A.W. Gelb, E. Stazi, L. Titi, F.P.

IV. History of anaesthesia in Colombia: periods of development

M.A. Tooley, C.L. Stapleton, G.L. Greenslade, C Prys-Roberts

Grand mal convulsion and plasma concentrations after intravascular injection of ropivacaine for axillary brachial plexus blockade M. Mu¨ller, R.J. Litz,

Unconscious learning during surgery with propofol anaesthesia†

Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints M. Iannuzzi,

D Frasca, C Dahyot-Fizelier, W Couet, B Debaene, O Mimoz, S Marchand

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

E. C. Hessian, B. E. Evans, J. A. Woods, D. J. Taylor, E Kinkel, A. R

Effect of concentration of local anaesthetic solution on the ED50 of bupivacaine for supraclavicular brachial plexus block† P.K. Gupta, P.M. Hopkins

Closed-loop control of propofol anaesthesia using bispectral index™: performance assessment in patients receiving computer-controlled propofol and manually.

R.L. Johnson, E.K. Cannon, C.B. Mantilla, D.A. Cook

R. Parke, S. McGuinness, R. Dixon, A. Jull

Analysis of pharmacodynamic interaction of sevoflurane and propofol on bispectral index during general anaesthesia using a response surface model J.C.

Presentation transcript:

Impact of propofol on mid-latency auditory-evoked potentials in children† G.E. Kuhnle, C. Hornuss, M. Lenk, A.P. Salam, D. Wiepcke, V. Edelmann-Gahr, G. Flake, M. Daunderer, M. Oberhauser, H.-H. Müller, M. Feuerecker British Journal of Anaesthesia Volume 110, Issue 6, Pages 1001-1009 (June 2013) DOI: 10.1093/bja/aet002 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 Peak latencies Na, Pa, Nb, and P1 at different conditions; multiple adjusted P-values after closed testing using the Page test and the Wilcoxon signed-rank test. Symbols for statistical significance: *indicates comparison with the 0 µg ml−1 group, #with the 3 µg ml−1 group, †with the 6 µg ml−1 group, and §with the 9 µg ml−1 group. One symbol reflects a P-value of <0.05, two symbols a P-value of <0.01, and three symbols a P-value of <0.001. Owing to the applied measuring system, the upper limit was set at 100 ms; therefore, peak latencies Nb and P1 experience an artificial ceiling effect at propofol concentrations of 6 and 9 µg ml−1. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 Original MLAEP curves of an 11-yr-old boy. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 Comparison of the peak latency differences Na/Pa, Pa/Nb, and Nb/P1 at different conditions; multiple adjusted P-values after closed testing using the Page test and the Wilcoxon signed-rank test. Symbols for statistical significance: *indicates comparison with the 0 µg ml−1 group, #with the 3 µg ml−1 group, †with the 6 µg ml−1 group, and §with the 9 µg ml−1 group. One symbol reflects a P-value of <0.05, two symbols a P-value of <0.01, and three symbols a P-value of <0.001. As the upper measuring limit was set at 100 ms, peak latency difference Nb/P1 experienced for propofol concentrations of 6 and 9 µg ml−1 an artificial ceiling effect. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions

Fig 4 MLAEP peak latencies Na, Pa, and Nb in correlation with propofol plasma concentration; sigmoidal dose–response model, curve fitted. Owing to the applied measuring system, the upper limit was set at 100 ms; therefore, peak latencies Nb and P1 experience an artificial ceiling effect at propofol concentrations of 6 and 9 µg ml−1. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions

Fig 5 MLAEP differences in amplitudes, Na/Pa, and Pa/Nb in correlation with propofol plasma concentration; sigmoidal dose–response model, curve fitted. As the upper measuring limit was set at 100 ms, peak latency difference Nb/P1 experienced for propofol concentrations of 6 and 9 µg ml−1 an artificial ceiling effect. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions

Fig 6 Modified AEP index: (a) box-plots of the modified AEP index at the respective propofol target concentrations; (b) measured plasma concentrations in correlation with the modified AEP index. Symbols for statistical significance: *indicates comparison with the 0 µg ml−1 group, #with the 3 µg ml−1 group, †with the 6 µg ml−1 group, and §with the 9 µg ml−1 group. One symbol reflects a P-value of <0.05, two symbols a P-value of <0.01, and three symbols a P-value of <0.001. British Journal of Anaesthesia 2013 110, 1001-1009DOI: (10.1093/bja/aet002) Copyright © 2013 The Author(s) Terms and Conditions