Evaluation of vancomycin MIC creep in methicillin-resistant Staphylococcus aureus infections—a systematic review and meta-analysis R. Diaz, V. Afreixo,

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Evaluation of vancomycin MIC creep in methicillin-resistant Staphylococcus aureus infections—a systematic review and meta-analysis R. Diaz, V. Afreixo, E. Ramalheira, C. Rodrigues, B. Gago Clinical Microbiology and Infection Volume 24, Issue 2, Pages 97-104 (February 2018) DOI: 10.1016/j.cmi.2017.06.017 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Results of literature search. Clinical Microbiology and Infection 2018 24, 97-104DOI: (10.1016/j.cmi.2017.06.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Pooled mean of vancomycin MIC determined by the broth microdilution method over time. The bubble size represents the meta-analysis sub-group weight. Clinical Microbiology and Infection 2018 24, 97-104DOI: (10.1016/j.cmi.2017.06.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Pooled mean vancomycin MIC determined by the Etest method over time. The bubble size represents the meta-analysis sub-group weight. Clinical Microbiology and Infection 2018 24, 97-104DOI: (10.1016/j.cmi.2017.06.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 Pooled proportion of methicillin-resistant Staphylococcus aureus isolates with vancomycin MIC ≥2 mg/L determined with the broth microdilution method. The bubble size represents the meta-analysis sub-group weight. Clinical Microbiology and Infection 2018 24, 97-104DOI: (10.1016/j.cmi.2017.06.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 5 Pooled proportion of methicillin-resistant Staphylococcus aureus isolates with vancomycin MIC ≥2 mg/L determined with the Etest method. The bubble size represents the meta-analysis sub-group weight. Clinical Microbiology and Infection 2018 24, 97-104DOI: (10.1016/j.cmi.2017.06.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions