Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis S. Groeneboer, M.Sc., P. Pastoureau, M.D., Ph.D., E.

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Presentation transcript:

Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis S. Groeneboer, M.Sc., P. Pastoureau, M.D., Ph.D., E. Vignon, M.D., Ph.D., B. Vander Cruyssen, M.D., Ph.D. Medical Sciences, D. Elewaut, M.D., Ph.D., G. Verbruggen, M.D., Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 9, Pages 986-993 (September 2008) DOI: 10.1016/j.joca.2008.01.005 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Weight gain of each treatment group over time. Fourteen rabbits underwent a sham surgery. A total of 41 rabbits underwent ACLT surgery. Twelve rabbits were then treated with saline (ACLT), 14 with 0.25mg/kg CDPS and 15 with 1mg/kg CDPS. Values represent mean±1 s.e.m. Osteoarthritis and Cartilage 2008 16, 986-993DOI: (10.1016/j.joca.2008.01.005) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (1) A: Mean macroscopic VAS score of medial femoral condyles and tibial plateaus of sham rabbits (SH, n=14), ACLT rabbits treated with saline (ACLT) (n=12), 0.25mg/kg CDPS (n=14) or 1mg/kg CDPS (n=15). B: Mean macroscopic VAS score of lateral femoral condyles and tibial plateaus of the four treatment groups. Bars represent mean±1 s.e.m. (2) A: Severity of osteophytes at the medial tibial plateaus and femoral condyles of sham-treated rabbits (SH) and rabbits that underwent ACLT treated with saline (ACLT), 0.25mg/kg CDPS or 1mg/kg CDPS. B: Variation in osteophyte severity at the lateral tibial plateaus and femoral condyles of the four treatment groups. Bars represent mean scores of tibial plateaus and femoral condyles ±1 s.e.m. Osteoarthritis and Cartilage 2008 16, 986-993DOI: (10.1016/j.joca.2008.01.005) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Safranin-O staining of a representative marginal area of a tibial plateau of a (A) sham-operated control, (B) ACLT knee with fibrillated cartilage surface, loss of superficial safranin-O staining (*), and obvious osteophyte formation (**), (C) 1.00mg/kg CDPS-treated ACLT rabbit showing small osteophyte (**), and (D) 0.25mg/kg CDPS-treated ACLT rabbit with cartilage ulceration on the central part of the lateral half of the tibial plateau (*). Original magnification ×25. Osteoarthritis and Cartilage 2008 16, 986-993DOI: (10.1016/j.joca.2008.01.005) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Histological evaluation of osteophytes at the femoral condyles and the tibial plateau of sham-treated animals and rabbits that underwent ACLT treated with saline (ACLT), 0.25mg/kg CDPS or 1mg/kg CDPS. Bars represent mean±1 s.e.m. Osteoarthritis and Cartilage 2008 16, 986-993DOI: (10.1016/j.joca.2008.01.005) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Histopathologic composite scores evaluated in the four groups of animals. Results are presented as individual data points, and the median for each group is indicated by the horizontal bar. *P<0.05 vs ACLT by a 1-side exact Mann–Whitney U test. Osteoarthritis and Cartilage 2008 16, 986-993DOI: (10.1016/j.joca.2008.01.005) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions