Volume 39, Issue 1, Pages (July 2003)

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Volume 39, Issue 1, Pages 86-92 (July 2003) Role of c-kit receptor tyrosine kinase-mediated signal transduction in proliferation of bile epithelial cells in young rats after ligation of bile duct: a study using Ws/Ws c-kit mutant rats Makoto Satake, Koichi Shimano, Takashi Yamamoto, Atsuhito Okaya, Teruo Iwasaki, Michiko Kakihana, Jiro Fujimoto, Nobuyuki Terada, Tohru Tsujimura Journal of Hepatology Volume 39, Issue 1, Pages 86-92 (July 2003) DOI: 10.1016/S0168-8278(03)00149-1

Fig. 1 Effects of BDL on serum bilirubin and ALT in +/+ and Ws/Ws rats. (A) Total bilirubin; and (B) ALT. Rats at the age of 2 or 6 weeks underwent SHAM (S) or BDL (B), and the concentrations of serum bilirubin and the values of serum ALT were measured on day 4 after operations. *P<0.05, significant difference by the corrected Mann–Whitney tests. Journal of Hepatology 2003 39, 86-92DOI: (10.1016/S0168-8278(03)00149-1)

Fig. 2 Liver sections of +/+ and Ws/Ws rats that underwent BDL. (A, B) BDL-2-week-old +/+ rat; (C, D) BDL-2-week-old Ws/Ws rat; (E, F) BDL-6-week-old +/+ rat; and (G, H) BDL-6-week-old Ws/Ws rat. Sections (A, C, E, and G) were stained with hematoxylin-eosin and their adjacent sections (B, D, F, and H) were immunostained with CK-19 antibody (original magnification×160). Journal of Hepatology 2003 39, 86-92DOI: (10.1016/S0168-8278(03)00149-1)

Fig. 3 Numbers of CK-19 positive cells in the portal field of the livers of +/+ and Ws/Ws rats. Rats at the age of 2 or 6 weeks underwent SHAM (S) or BDL (B), and numbers of CK-19 positive cells per portal field (0.5×0.5 mm2) were counted on day 4 after operations. Bars indicate means±SE. *P<0.05, significant difference by unpaired, two-tailed Student's t-test. Journal of Hepatology 2003 39, 86-92DOI: (10.1016/S0168-8278(03)00149-1)

Fig. 4 Ki-67 labeling indices of BEC of +/+ and Ws/Ws rats. Rats at the age of 2 or 6 weeks underwent SHAM (S) or BDL (B), and Ki-67 labeling indices were examined on day 4 after operations. Bars indicate means±SE. *P<0.05, significant difference by unpaired, two-tailed Student's t-test. Journal of Hepatology 2003 39, 86-92DOI: (10.1016/S0168-8278(03)00149-1)

Fig. 5 Expression of KIT in BEC of BDL-2-week-old rats. (A) BDL-2-week-old +/+ rat; and (B) BDL-2-week-old Ws/Ws rat. Each liver section of 2-week-old +/+ and Ws/Ws rats that underwent BDL was immunostained with KIT antibody. Arrows indicate BEC immunoreacted with KIT antibody (original magnification×183). Journal of Hepatology 2003 39, 86-92DOI: (10.1016/S0168-8278(03)00149-1)