Introduction to medical immunology This powerpoint file is new …to be added to “Serotonin” files Introduction to medical immunology Ali Al Khader, MD Faculty of Medicine Al-Balqa’ Applied University Email: ali.alkhader@bau.edu.jo

Lines of defense *We have 2 lines of defense: -First line: Innate immune system (including mechanical barriers) -Second line: Adaptive immune system *In some textbooks: 3 lines of defense…considering mechanical barriers alone as the first line of defense followed by innate immune system then adaptive immune system

Innate immune system = “natural” = “native” -Germline: prepared before exposure …the defense is direct or just needs some activation after exposure -Mainly against microbes -With repetition…the response is the same -Identify groups of related microbes…not distinguishing fine differences …limited diversity

Adaptive immune system = “acquired” = “specific” It adapts: performance with repetitive exposure…the ability to remember High specificity… distinguishing fine differences…the specific target molecules = antigens Large diversity… by somatic recombination of gene segments Immunoglobulins…by B lymphocytes ..will be explained later

1ry VS 2ry lymphoid organs …they are the organs or tissue in which lymphocytes are produced …they are: -Bone marrow (postnatally) & yolk sac/fetal liver/fetal spleen (in embryo) …where both B & T lymphocytes are produced -Thymus…where T lymphocytes development is completed *Note: by puberty, most lymphopoiesis is of B type (in the marrow of flat bones) 2ry lymphoid organs: …they are the organs or tissue where: …they are: lymph nodes, spleen, mucosa-associated lymphoid tissues (MALT) & skin Lymphocytes come into contact with foreign antigen, are clonally expanded & mature into effector cells

Our syllabus (by powerpoint files) Our syllabus and a brief general introduction Components of innate immune system Reactions of innate immunity Antigens Major histocompatibility complex (MHC) Immunoglobulins 1 + tests to detect antigens and antibodies Immunoglobulins 2 Complement system Development of T and B lymphocytes T cell-mediated immunity Effector mechanisms of humoral immunity Mucosal immunity Clinical cases Immunological tolerance Autoimmune diseases Hypersensitivity Immunodeficiency 1 Immunodeficiency 2 Vaccinations 1 Vaccinations 2 Transplantation immunology Tumor immunology Immunohematology

Our schedule until 29/10/2018 23/9 Sun 25/9 Tue 30/9 Sun 2/10 Tue 10/10 Wed 14/10 Sun 16/10 Tue 21/10 Sun XXX …added XXX 14-18/10 XXX XXX 22-29/10 XXX