Urinary tract infections revisited

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Presentation transcript:

Urinary tract infections revisited G. Godaly, C. Svanborg Kidney International Volume 71, Issue 8, Pages 721-723 (April 2007) DOI: 10.1038/sj.ki.5002170 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Fully virulent uro-pathogenic Escherichia coli possess a wide arsenal of virulence factors and cause severe infections such as pyelonephritis and bacteremia. P fimbriated E. coli adhere to the Galα1®4Galβ receptor epitope in the globoseries of glycosphingolipids on the uro-epithelium and activate epithelial cells through Toll-like receptor 4 (TLR4) and the adaptor proteins TRIF and TRAM. Type 1 fimbriae recognize N-linked mannose residues in a wide range of glycoproteins. The response to type 1 fimbriated strains is also TLR4 dependent but involves lipopolysaccharide and the adaptor molecule MyD88. The different adaptor protein usage might thus contribute to the observed differences in chemokine repertoire. Kidney International 2007 71, 721-723DOI: (10.1038/sj.ki.5002170) Copyright © 2007 International Society of Nephrology Terms and Conditions