Biology of Blood and Marrow Transplantation

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Presentation transcript:

Biology of Blood and Marrow Transplantation Functional Signatures Revealed by Deep Phenotyping of CMV-Specific CD8+ T Cells Predict Risk of Early CMV Reactivation after Allogeneic Hematopoietic Cell Transplantation Jose F. Camargo, Eric Wieder, Erik Kimble, Cara L. Benjamin, Despina Kolonias, Gabriela Bravo, Krishna V. Komanduri Biology of Blood and Marrow Transplantation Volume 24, Issue 3, (March 2018) DOI: 10.1016/j.bbmt.2017.12.678 Copyright © 2017 Terms and Conditions

Figure 1 Proctective (PS) and non-protective (NPS) cytokine signatures in CMV seropositive HCT recipients (n = 30). (A and B) Frequency of IL-2negIFNɣposTNFɑnegMIP-1ßpos (NPS, panel A) and IL-2posIFNɣposTNFɑposMIP-1ßpos (PS, panel B) across CMV risk group (n = 10 each). EC, elite controllers; SC, spontaneous controllers; NC, non controllers: C-D Frequency of NPS (Panel C) and PS (panel D) by number of CMV reactivation episodes. P-value corresponds to comparison between groups by using Wilcoxon Mann–Whitney test *P < .05 **P < .01. Biology of Blood and Marrow Transplantation 2018 24, DOI: (10.1016/j.bbmt.2017.12.678) Copyright © 2017 Terms and Conditions

Figure 2 Cumulative incidence of progressive CMV viremia predicted by combined signatures. Progressive CM viremia was defined as CMV reactivation with peak viral load >1000 IU/mL that required initiation of pre-emptive antiviral therapy. The group of patients with low (<2%) levels of the protective signature (PS) IL-2posIFNɣposTNFɑposMIP-1ßpos and high (>10%) levels of the non-protective signature (NPS) IL-2negIFNɣposTNFɑnegMIP-1ßpos is shown in red (n = 10). Other patients are shown in blue (n = 20). Signatures correspond to cytokine flow cytometry performed using stimulation with CMV-pp65 at day +30 post-transplant. Biology of Blood and Marrow Transplantation 2018 24, DOI: (10.1016/j.bbmt.2017.12.678) Copyright © 2017 Terms and Conditions