Volume 50, Issue 2, Pages 426-431 (February 2009) Acute hepatitis B in a healthcare worker: A case report of genuine vaccination failure  Hein J. Boot, Laurens A. van der Waaij, Jurjen Schirm, Cees G.M. Kallenberg, Jim van Steenbergen, Bert Wolters  Journal of Hepatology  Volume 50, Issue 2, Pages 426-431 (February 2009) DOI: 10.1016/j.jhep.2008.07.040 Copyright © 2008 European Association for the Study of the Liver Terms and Conditions

Fig. 1 History of hepatitis B vaccination and relevant serologic analysis prior to the onset of acute hepatitis B in 2007. Journal of Hepatology 2009 50, 426-431DOI: (10.1016/j.jhep.2008.07.040) Copyright © 2008 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Phylogenetic tree (neighbour-joining algorithm, 250 bootstraps) of acute hepatitis B virus (HBV) isolates from the Netherlands. All available sequences of acute HBV strains of the last 6months of 2004 as well as the HBV isolate of our patient (MSM vaccine failure) were analysed. The most likely source of transmission is indicated for each strain (MSM=men who have sex with men; hetero=heterosexual contact; other=multiple routes, e.g. dentist, hairdresser, etc.; unknown=no transmission data available). Prototype genotype A strains are indicated by their genbank accession number. Journal of Hepatology 2009 50, 426-431DOI: (10.1016/j.jhep.2008.07.040) Copyright © 2008 European Association for the Study of the Liver Terms and Conditions