Does BCG vaccination protect against childhood asthma

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Presentation transcript:

Does BCG vaccination protect against childhood asthma Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis Mary F. Linehan, PhD, Ulugbek Nurmatov, PhD, Timothy L. Frank, MD, Robert M. Niven, MD, David N. Baxter, PhD, Aziz Sheikh, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 3, Pages 688-695.e14 (March 2014) DOI: 10.1016/j.jaci.2013.08.007 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, Forest plot (fixed-effects model) showing ORs and 95% CIs for the association between BCG vaccination and asthma. B, Funnel plot for the association between BCG vaccination and asthma. C, Forest plot (random-effects model) showing ORs and 95% CIs for the association between BCG vaccination and asthma in category B studies. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 A, Forest plot (random-effects model) showing ORs and 95% CIs for the association between BCG vaccination and sensitization measured by using specific IgE level. B, Funnel plot for the association between BCG vaccination and a positive specific IgE level. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 A, Forest plot (fixed-effects model) showing ORs and 95% CIs for the association between BCG vaccination and a positive SPT response. B, Funnel plot for the association between BCG vaccination and a positive SPT response. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 A, Forest plot (random-effects model) showing ORs and 95% CIs for the association between BCG and atopic dermatitis/eczema. B, Funnel plot for the association between BCG vaccination and eczema/atopic dermatitis. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 A, Forest plot (random-effects model) showing ORs and 95% CIs for the association between BCG and allergic rhinoconjunctivitis. B, Funnel plot for the association between BCG vaccination and rhinoconjunctivitis. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 A, Forest plot (fixed-effects model) showing ORs and 95% CIs for the association between BCG vaccination and allergy in general. B, Funnel plot for the association between BCG vaccination and allergy in general. C, Forest plot (fixed-effects model) showing ORs and 95% CIs for the association between BCG vaccination and allergy in general in category B studies. Journal of Allergy and Clinical Immunology 2014 133, 688-695.e14DOI: (10.1016/j.jaci.2013.08.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions