Molecular Therapy - Nucleic Acids

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Molecular Therapy - Nucleic Acids Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics Bao T. Le, Prithi Raguraman, Tamer R. Kosbar, Susan Fletcher, Steve D. Wilton, Rakesh N. Veedu Molecular Therapy - Nucleic Acids Volume 14, Pages 142-157 (March 2019) DOI: 10.1016/j.omtn.2018.11.007 Copyright © 2018 The Author(s) Terms and Conditions

Figure 1 Antisense Oligonucleotide Mechanisms to Alter Gene Expression Different colors in pre-mRNA structure indicate introns and exons. Molecular Therapy - Nucleic Acids 2019 14, 142-157DOI: (10.1016/j.omtn.2018.11.007) Copyright © 2018 The Author(s) Terms and Conditions

Figure 2 Examples of Prominent Chemically Modified Nucleotides Molecular Therapy - Nucleic Acids 2019 14, 142-157DOI: (10.1016/j.omtn.2018.11.007) Copyright © 2018 The Author(s) Terms and Conditions

Figure 3 Design of Gapmer and Mixmer AO Constructs Green blocks: modified nucleotides; yellow blocks: normal nucleotides. Molecular Therapy - Nucleic Acids 2019 14, 142-157DOI: (10.1016/j.omtn.2018.11.007) Copyright © 2018 The Author(s) Terms and Conditions

Figure 4 Discovery Timeline of Angiogenic Factors Molecular Therapy - Nucleic Acids 2019 14, 142-157DOI: (10.1016/j.omtn.2018.11.007) Copyright © 2018 The Author(s) Terms and Conditions