Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation  Omar Tliba, PhD, DVM, Reynold A. Panettieri, MD  Journal of Allergy and Clinical Immunology  Volume 143, Issue 4, Pages 1287-1294 (April 2019) DOI: 10.1016/j.jaci.2018.06.008 Copyright © 2018 The Authors Terms and Conditions

Fig 1 Conceptual model of the pathobiology of PGA. A variety of triggers induce alterations in structural cell function (myofibroblasts and epithelial, smooth muscle, and mast cells) that engender AHR. Typically, patients with PGA manifest insensitivity to corticosteroid therapy. In a corticosteroid-insensitive manner structural cells also modulate airway inflammatory responses, such as chemokine and cytokine secretion and leukocyte trafficking. Ach, Acetylcholine; M2R, muscarinic receptor 2; M3R, muscarinic receptor 3. Journal of Allergy and Clinical Immunology 2019 143, 1287-1294DOI: (10.1016/j.jaci.2018.06.008) Copyright © 2018 The Authors Terms and Conditions