The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis Kevin Quach,

Slides:

Advertisements

Similar presentations

American Journal of Kidney Diseases

Advertisements

John W. Pickering, PhD, Matthew T. James, MD, PhD, FRCPC, Suetonia C

Prognostic Value of Morning Blood Pressure Surge in Clinical Events: A Meta-analysis of Longitudinal Studies Jun-Chao Xie, Han Yan, Yan-Xin Zhao, PhD,

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies Christos G. Mihos, DO, Romain Capoulade, PhD, Evin Yucel,

Wan-Jie Gu, MSc, Chun-Yin Wei, MSc, Rui-Xing Yin, MD, PhD CHEST

Alfred A. Bartolucci, PhD, Michal Tendera, MD, George Howard, DrPH

Does Exercise Reduce Pain and Improve Physical Function Before Hip or Knee Replacement Surgery? A Systematic Review and Meta-Analysis of Randomized Controlled.

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review Shelley R. Salpeter, MD, Jacob S.

Courtney J. Warner, MD, MS, Spencer W. Greaves, MPH, Robin J

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase.

Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis S Hajibandeh, S Hajibandeh,

Safety and Efficacy of Incretin-Based Therapies in Patients With Type 2 Diabetes Mellitus and CKD: A Systematic Review and Meta-analysis Patricia M.

Dialysis Catheter–Related Bloodstream Infections: A Cluster-Randomized Trial of the ClearGuard HD Antimicrobial Barrier Cap Jeffrey L. Hymes, MD, Ann.

30-Day Readmissions After an Acute Kidney Injury Hospitalization

Gregory L. Hundemer, MD, MPH, Andrew Z. Fenves, MD, Kristy M

Phosphate Kinetic Models in Hemodialysis: A Systematic Review

Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical.

Empirically Derived Search Filters for the Development of Kidney Disease Clinical Practice Guidelines Pavel S. Roshanov, MD, MSc, Arthur V. Iansavichus,

Treatment of Uremic Pruritus: A Systematic Review

Erratum Regarding “Preemptive Correction of Arteriovenous Access Stenosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials” (Am.

A Randomized, Single-Blind, Crossover Trial of Recovery Time in High-Flux Hemodialysis and Hemodiafiltration James R. Smith, MBChB, Norica Zimmer, MD,

Dialysis Facility Ownership and Epoetin Dosing in Hemodialysis Patients: A Dialysis Provider’s Perspective J. Michael Lazarus, MD, Raymond M. Hakim,

David J. Tunnicliffe, Suetonia C. Palmer

Sevelamer Prescriptions After Reporting of the Dialysis Clinical Outcomes Revisited (DCOR) Trial Findings: An Analysis of 5,495 Patients Receiving Maintenance.

Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials Suetonia C. Palmer, PhD, Sharon Gardner, MA, Marcello Tonelli,

Evaluating the Contribution of the Cause of Kidney Disease to Prognosis in CKD: Results From the Study of Heart and Renal Protection (SHARP) Richard.

Task-sharing interventions for cardiovascular risk reduction and lipid outcomes in low- and middle-income countries: A systematic review and meta-analysis

Coronary artery bypass grafting is superior to first-generation drug-eluting stents for unprotected left main coronary artery disease: An updated meta-analysis.

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies Christos G. Mihos, DO, Romain Capoulade, PhD, Evin Yucel,

Acute Kidney Injury and Death Associated With Renin Angiotensin System Blockade in Cardiothoracic Surgery: A Meta-analysis of Observational Studies Rabi.

Volatile anesthetics in preventing acute kidney injury after cardiac surgery: A systematic review and meta-analysis Jieru Cai, MD, Rende Xu, MD, PhD,

Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD Rachael L. Morton, PhD, Iryna Schlackow, DPhil, Natalie Staplin, PhD, Alastair.

Zheng-Zhe Feng, MD, Jian Shi, MD, Xue-Wei Zhao, MD, Zhi-Fei Xu, MD

Augmented Nurse Care Management in CKD Stages 4 to 5: A Randomized Trial Steven Fishbane, MD, Sofia Agoritsas, MPA, Alessandro Bellucci, MD, Candice Halinski,

Erratum Regarding “Ultrasound Monitoring to Detect Access Stenosis in Hemodialysis Patients: A Systematic Review” (Am J Kidney Dis. 2008;51(4): )

Prehypertension and Incidence of ESRD: A Systematic Review and Meta-analysis Yuli Huang, MD, Xiaoyan Cai, MD, Jianyu Zhang, MD, Weiyi Mai, MD, PhD, Sheng.

Second-line or Subsequent Systemic Therapy for Recurrent or Progressive Non-Small Cell Lung Cancer: A Systematic Review and Practice Guideline J Noble,

Karin Franco Pinotti, MD, Fellow PhD, Daniele C

Cabergoline for the prevention of ovarian hyperstimulation syndrome: systematic review and meta-analysis of randomized controlled trials Valeria M.S.

Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical.

Yousef Rezaei, MD American Journal of Kidney Diseases

Hemoglobin Level and Transfusions in Patients on Maintenance Dialysis: Where the Rubber Meets the Road Eduardo Lacson, MD, MPH, Franklin Maddux, MD

Effect of Intensive Insulin Therapy and Pentastarch Resuscitation on Acute Kidney Injury in Severe Sepsis George Thomas, MD, MPH, Ethan M. Balk, MD,

Percutaneous transluminal angioplasty versus primary stenting in infrapopliteal arterial disease: A meta-analysis of randomized trials Ridong Wu, MD,

Sankar D. Navaneethan, MD, MPH, Suetonia C. Palmer, MBChB, Jonathan C

The Map Is Not the Territory—Mapping Out the Course and Cost of CKD

Kidney Disease End Points in a Pooled Analysis of Individual Patient–Level Data From a Large Clinical Trials Program of the Dipeptidyl Peptidase 4 Inhibitor.

Anaortic off-pump coronary artery bypass grafting: The criterion standard for minimization of neurologic injury J. James Edelman, BSc(Hons), MBBS(Hons),

Use of Diuretics in Heart Failure: A Precarious Balance

Effect of diastolic dysfunction on postoperative outcomes after cardiovascular surgery: A systematic review and meta-analysis Roop Kaw, MD, Adrian V.

Study Designs in Patient-Oriented Research

Role of Niacin in Current Clinical Practice: A Systematic Review

Daniel E. Weiner, MD, MS, Mark J. Sarnak, MD, MS

One-way Versus Two-way Text Messaging on Improving Medication Adherence: Meta- analysis of Randomized Trials David S. Wald, MD, FRCP, Shahena Butt, MSc,

KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 Update of Hemoglobin Target American.

Trial Quality in Nephrology: How Are We Measuring Up?

Multidrug-Resistant Organisms Within the Dialysis Population: A Potentially Preventable Perfect Storm David P. Calfee, MD, MS American Journal of Kidney.

Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery

The Journal of Thoracic and Cardiovascular Surgery

This Month in AJKD American Journal of Kidney Diseases

Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials Suetonia C. Palmer, PhD, Sharon Gardner, MA, Marcello Tonelli,

Dialysis Research and N-of-1 Trials: Made for Each Other?

Clinical Practice Recommendations For Peritoneal Dialysis Adequacy

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta- analysis of randomized controlled trials Michael N. Mavros, MD, Pantelis.

Volume 68, Issue 4, Pages (October 2005)

Clinical Practice Guidelines for Peritoneal Dialysis Adequacy

Quiz page December 2003 American Journal of Kidney Diseases

Catheter Type, Placement, and Insertion Techniques for Preventing Catheter-Related Infections in Maintenance Peritoneal Dialysis Patients: Summary of.

Presentation transcript:

The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis Kevin Quach, MSc, Lyubov Lvtvyn, MSc, Colin Baigent, FRCP, Joe Bueti, MD, Amit X. Garg, MD, PhD, Carmel Hawley, MBBS, MMedSci, Richard Haynes, DM, Braden Manns, MD, MSc, Vlado Perkovic, MD, PhD, Christian G. Rabbat, MD, MSc, Ron Wald, MDCM, MPH, Michael Walsh, MD, PhD American Journal of Kidney Diseases Volume 68, Issue 4, Pages 591-598 (October 2016) DOI: 10.1053/j.ajkd.2016.04.011 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Flow diagram of search selection. Abbreviation: RCT, randomized controlled trial. American Journal of Kidney Diseases 2016 68, 591-598DOI: (10.1053/j.ajkd.2016.04.011) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Forest plot of the effects of mineralocorticoid receptor antagonists (MRAs) on cardiovascular mortality in dialysis patients. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel. American Journal of Kidney Diseases 2016 68, 591-598DOI: (10.1053/j.ajkd.2016.04.011) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Forest plot of the effect of mineralocorticoid receptor antagonists (MRAs) on all-cause mortality in dialysis patients. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel. American Journal of Kidney Diseases 2016 68, 591-598DOI: (10.1053/j.ajkd.2016.04.011) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Forest plot of the effect of mineralocorticoid receptor antagonists (MRAs) on hyperkalemia in dialysis patients. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel. American Journal of Kidney Diseases 2016 68, 591-598DOI: (10.1053/j.ajkd.2016.04.011) Copyright © 2016 The Authors Terms and Conditions