Volume 25, Issue 4, Pages (December 2018)

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Volume 25, Issue 4, Pages 335-345 (December 2018) SPOP, ZEB-1 and E-cadherin expression in clear cell renal cell carcinoma (cc-RCC): Clinicopathological and prognostic significance Ola A. Harb, Mariem A. Elfeky, Basant Sh El Shafaay, Heba F. Taha, Gamal Osman, Ibtsam Shehta Harera, Loay M. Gertallah, Doaa Metwaly Abdelmonem, Ahmed Embaby Pathophysiology Volume 25, Issue 4, Pages 335-345 (December 2018) DOI: 10.1016/j.pathophys.2018.05.004 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 Immunohistochemical expression of SPOP in clear cell renal cell carcinoma (cc-RCC): (A) High expression in the cytoplasm of cc-RCC grade IV stage IVx400 (B) High expression in the cytoplasm of cc-RCC grade III stage IIIx400 (C) High expression in the cytoplasm of cc-RCC grade II stage IIx400 (D) Low expression in the cytoplasm of cc-RCC grade I stage Ix400 Low expression in the cytoplasm of cc-RCC grade I stage I x400. (E) & (F) Low expression in the cytoplasm of the proximal convoluted tubules of normal kidney. Note: High SPOP immunohistochemical expression in high grade & stage cc-RCC and low expression in normal kidney tissue and in low grade & stage cc-RCC. Pathophysiology 2018 25, 335-345DOI: (10.1016/j.pathophys.2018.05.004) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 Immunohistochemical expression of ZEB-1 in clear cell renal cell carcinoma (cc-RCC):(A) High expression in the nucleus of cc-RCC grade IV stage IVx400 (B) High expression in the nucleus of cc-RCC grade III stage IIIx400 (C)) High expression in the nucleus of cc-RCC grade II stage IIx400 (D) Low expression in the nucleus of cc-RCC grade I stage Ix400 (E) & (F) Low expression in the nucleus of the proximal convoluted tubules of normal kidney. Note: High ZEB-1 immunohistochemical expression in high grade & stage cc-RCC and low expression in normal kidney tissue and in low grade & stage cc-RCC. Pathophysiology 2018 25, 335-345DOI: (10.1016/j.pathophys.2018.05.004) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Immunohistochemical expression of E-cadherin in clear cell renal cell carcinoma (cc-RCC): (A) high membranous expression in cc-RCC grade I stage Ix400 (B) high membranous expression in cc-RCC grade II stage II x400 (C) low membranous expression in cc-RCC grade II stage IIIx400 (D) high membranous expression in the proximal convoluted tubules of normal kidney (E) low membranous expression in cc-RCC grade III stage IIIx400, (E) low membranous expression in cc-RCC grade IV stage IVx400. Note: High E-cadherin membranous expression in normal kidney tissue and in low grade & stage cc-RCC and low expression in high grade & stage cc-RCC. Pathophysiology 2018 25, 335-345DOI: (10.1016/j.pathophys.2018.05.004) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 4 Kaplan Meir survival curves of overall survival rate (OS) of the studied cc-RCC patients (A) OS rate of all the studied cc-RCC cases (B) OS rate stratified according to SPOP expression (C) OS rate stratified according to ZEB 1 expression (D) OS rate stratified according to E-cadherin expression. Pathophysiology 2018 25, 335-345DOI: (10.1016/j.pathophys.2018.05.004) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 5 Kaplan Meir survival curves of progression free survival (PFS) of the studied cc-RCC patients (A) PFS rate of all the studied cc-RCC cases (B) PFS rate stratified according to SPOP expression (C) PFS rate stratified according to ZEB 1 expression (D) PFS rate stratified according to E-cadherin expression. Pathophysiology 2018 25, 335-345DOI: (10.1016/j.pathophys.2018.05.004) Copyright © 2018 Elsevier B.V. Terms and Conditions