Prevention of vein graft intimal hyperplasia with photochemical tissue passivation Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C. McCormack, MBA, Justin R. Fernandes, MD, Lisa Gfrerer, MD, Michael T. Watkins, MD, Robert W. Redmond, PhD, William G. Austen, MD Journal of Vascular Surgery Volume 65, Issue 1, Pages 190-196 (January 2017) DOI: 10.1016/j.jvs.2015.11.049 Copyright © 2015 Society for Vascular Surgery Terms and Conditions
Fig 1 Vein graft diameter before and after release of arterial clamps at the time of the initial procedure. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions
Fig 2 Photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) after clamp release. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions
Fig 3 Comparison of a photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) fixed 1 hour after placement of vein graft, stained with Verhoeff-van Gieson stain. The untreated control vein is excessively dilated and shows interruption of endothelium and distortion of intima, media, and adventitia. The PTP-treated vein is not excessively distended and demonstrates normal architecture. Scale bar = 0.25 mm. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions
Fig 4 Intimal thickness 4 weeks after placement of vein graft. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions
Fig 5 Representative histologic section of an untreated control vein (left column), rose bengal (RB, no light)-treated vein (middle column), and photochemical tissue passivation (PTP)-treated vein (right column) after 4 weeks. Note the substantially increased intimal thickness in the untreated control and RB (no light) veins compared with the PTP-treated vein. Scale bar = 0.25 mm. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions