Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C

Slides:



Advertisements
Similar presentations
Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:
Advertisements

Lucy Wales, FRCS, MD, Martin Gosling, PhD, Graham W
Large renal artery aneurysm in Takayasu arteritis
Diet-induced obesity drives negative mouse vein graft wall remodeling
Without prejudice Journal of Vascular Surgery
Dipeptidyl peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff  Akio Koyama, MD, Kimihiro.
Mark F. Fillinger, MD, Emanuel R. Reinitz, MD, Robert A
Dose responsive suppression of myointimal hyperplasia by dexamethasone
Ezetimibe reduces intimal hyperplasia in rabbit jugular vein graft
Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S
Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates  Alan B. Lumsden, MB, ChB, Changyi Chen,
Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers  Rob Hurks, MD, PhD, Rogier H.J. Kropman,
Dipeptidyl peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff  Akio Koyama, MD, Kimihiro.
Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia  Michael J. Osgood, MD, Kevin Sexton, MD, Igor Voskresensky, MD, Kyle.
A percutaneous arterial closure protocol can decrease complications after endovascular interventions in vascular surgery patients  Philip P. Goodney,
Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment  Masaki Kajimoto, MD, Takatsugu.
Adventitial delivery of platelet-derived endothelial cell growth factor gene prevented intimal hyperplasia of vein graft  Mitsuteru Handa, MD, Wei Li,
SS5. Lifeline Resident Research Prize Paper Decellularized Human Tissue Engineered Vessel as an Arterial Conduit  Clay Quint, Alan Dardik, Laura Niklason 
PC222. Loss of Normal Fiber Orientation in Human Abdominal Aortic Aneurysmal Tissue and Increased Energy Loss  Sandra Toth, BS, Doran Mix, MD, BS, Ibrahima.
Menno H. Raber, MD, Robbert Meerwaldt, MD, PhD, Rob J. van Det, MD 
Diet-induced obesity drives negative mouse vein graft wall remodeling
Mohamed A. Zayed, MD, PhD, Ronald L. Dalman, MD, Jason T. Lee, MD 
Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects)  William R. Hiatt,
Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft  Akio Kodama, MD, Kimihiro Komori, MD, PhD, Keisuke Hattori, MD,
The first operation on the profunda femoris artery
Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor β3  Jonathan Ghosh, MD, MRCS, Mohammed.
Impaired graft healing due to hypercholesterolemia is prevented by dietary supplementation with α-tocopherol  Keiko Miyazaki, MD, Scott M. Colles, PhD,
Gregory D. Jay, BE, BS, Frank L. Ross, MD, Robert A
Lowell S. Kabnick, MD  Journal of Vascular Surgery 
Without prejudice Journal of Vascular Surgery
Remodeling in peripheral vein graft revisions: Serial study with three-dimensional ultrasound imaging  Daniel F. Leotta, PhD, Jean F. Primozich, BS, Kirk.
Luigi Pascarella, MD, Geert W. Schmid-Schönbein, PhD, John Bergan, MD 
Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts  Helen M.
Adventitial delivery of platelet-derived endothelial cell growth factor gene prevented intimal hyperplasia of vein graft  Mitsuteru Handa, MD, Wei Li,
Split-thickness skin grafting the high-risk diabetic foot
The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression  John R. Hoch, MD, Vida K. Stark,
Inhibition of experimental neointimal hyperplasia by recombinant human thrombomodulin coated ePTFE stent grafts  Geoffrey Wong, MD, Jian-ming Li, MD,
Loss of lymphatic vessels and regional lipid accumulation is associated with great saphenous vein incompetence  Hiroki Tanaka, MD, Nobuhiro Zaima, PhD,
The future of vascular surgery
Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates  Alan B. Lumsden, MB, ChB, Changyi Chen,
Paul J. Riesenman, MD, MS, Mark A. Farber, MD, Robert R
First textbook in vascular surgery
Photodynamic therapy of vein grafts: Suppression of intimal hyperplasia of the vein graft but not the anastomosis  Glenn M. LaMuraglia, MD, Michael L.
Masson's tumor in the ulnar artery
Dissecting aneurysm of common iliac artery in a long-distance runner
Traumatic arteriovenous fistula 52 years after injury
Mark K. Hirko, MD, Joseph R. McShannic, MD, Steven P
Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J
Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P
Reply Journal of Vascular Surgery
Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD 
Molecular engineering of vein bypass grafts
Popliteal arterial aneurysm associated with Klippel-Trénaunay syndrome: Case report and literature review  Daisuke Akagi, MD, Shigeyuki Ishii, MD, Takeshi.
Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia  Giuseppe R Nigri, MD, PhD, Sylvie.
Functional analysis of cryopreserved veins
Immunosuppressive treatment of aortic allografts
Vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts  Mark Kissin, MD, Nikhil Kansal, MD, Peter.
Endovascular management of superior mesenteric artery pseudoaneurysm
David L. Dawson, MD, Jennifer Meyer, RCIS, Eugene S
André S. van Petersen, MD, Bianca H. Vriens, MD, Ad B
Endovascular repair of an acute blunt popliteal artery injury
Regarding “Vascular abnormalities in patients with neurofibromatosis syndrome type I: Clinical spectrum, management, and results”  John B. Chang, MD,
Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts  Hiroshi Banno, MD, Yoshifumi Takei, PhD,
Richard J. Sanders, MD 1, William H. Pearce, MD 2 
Circumferential heterogeneity in the abdominal aortic aneurysm wall composition suggests lateral sides to be more rupture prone  Rob Hurks, MD, Gerard.
Glenn C. Hunter, M.D., Stan N. Carson, M.D. 
Bhagwan Satiani, MD, MBA, Thomas E. Williams, MD, PhD, Michael R
Surgical repair of left internal jugular phlebectasia
Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review  Alexander W. Clowes, MD, Michael A. Reidy,
Prospective randomized study evaluating an absorbable cyanoacrylate for use in vascular reconstructions  Alan B. Lumsden, MD, Eugene R. Heyman, PhD  Journal.
Presentation transcript:

Prevention of vein graft intimal hyperplasia with photochemical tissue passivation  Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C. McCormack, MBA, Justin R. Fernandes, MD, Lisa Gfrerer, MD, Michael T. Watkins, MD, Robert W. Redmond, PhD, William G. Austen, MD  Journal of Vascular Surgery  Volume 65, Issue 1, Pages 190-196 (January 2017) DOI: 10.1016/j.jvs.2015.11.049 Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 1 Vein graft diameter before and after release of arterial clamps at the time of the initial procedure. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 2 Photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) after clamp release. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 3 Comparison of a photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) fixed 1 hour after placement of vein graft, stained with Verhoeff-van Gieson stain. The untreated control vein is excessively dilated and shows interruption of endothelium and distortion of intima, media, and adventitia. The PTP-treated vein is not excessively distended and demonstrates normal architecture. Scale bar = 0.25 mm. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 4 Intimal thickness 4 weeks after placement of vein graft. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 5 Representative histologic section of an untreated control vein (left column), rose bengal (RB, no light)-treated vein (middle column), and photochemical tissue passivation (PTP)-treated vein (right column) after 4 weeks. Note the substantially increased intimal thickness in the untreated control and RB (no light) veins compared with the PTP-treated vein. Scale bar = 0.25 mm. Journal of Vascular Surgery 2017 65, 190-196DOI: (10.1016/j.jvs.2015.11.049) Copyright © 2015 Society for Vascular Surgery Terms and Conditions