Volume 69, Issue 6, Pages 1396-1397 (December 2018) Incidence of grade 3-4 liver injury under immune checkpoints inhibitors: A retrospective study  Lucia Parlati, Anais Vallet-Pichard, Rui Batista, Alain Hernvann, Philippe Sogni, Stanislas Pol, Vincent Mallet  Journal of Hepatology  Volume 69, Issue 6, Pages 1396-1397 (December 2018) DOI: 10.1016/j.jhep.2018.08.014 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Frequencies of grade 3 and 4 AST/ALT/GGT/ALP and total bilirubin elevations among immune checkpoint inhibitor (n = 303) and control (n = 299,491) patients over an eight-year observational period in a teaching hospital. Differences between groups were computed with logistic regressions adjusted for age, sex, and prescription unit. **p <0.05, ***p <0.001. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transferase. Journal of Hepatology 2018 69, 1396-1397DOI: (10.1016/j.jhep.2018.08.014) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions