A large-scale genetic analysis reveals an autoimmune origin of idiopathic retroperitoneal fibrosis  Davide Martorana, PhD, Ana Márquez, PhD, F. David Carmona, PhD, Francesco Bonatti, PhD, Alessia Adorni, PhD, Maria L. Urban, MD, Federica Maritati, MD, Eugenia Accorsi Buttini, MD, Chiara Marvisi, MD, Alessandra Palmisano, MD, Giovanni M. Rossi, MD, Giorgio Trivioli, MD, Paride Fenaroli, MD, Lucio Manenti, MD, Maria Nicastro, BSS, Monia Incerti, BSS, Davide Gianfreda, MD, Stefano Bani, MD, Stefania Ferretti, MD, Domenico Corradi, MD, Federico Alberici, MD, PhD, Giacomo Emmi, MD, PhD, Gerardo Di Scala, MD, Gabriella Moroni, MD, Antonio Percesepe, MD, Paul J. Scheel, MD, Eric Vermeer, MD, PhD, Eric F. van Bommel, MD, Javier Martín, MD, PhD, Augusto Vaglio, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 5, Pages 1662-1665 (November 2018) DOI: 10.1016/j.jaci.2018.06.045 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Manhattan plot representing results of the meta-analysis, including the Italian and Dutch cohorts. Red and blue lines indicate established (P = 8.04 × 10−7) and suggestive (P = 1.61 × 10−5) significance levels, respectively. B, Manhattan plot showing results obtained in a meta-analysis of the HLA region (unconditioned test). C, Results after conditioning on the HLA-DRB1*0301 classical allele. The red/green color gradient represents the effect direction of each analyzed variant (red for risk and green for protection). Size of diamonds indicates the degree of linkage disequilibrium with the classical allele HLA-DRB1*0301. The red line represents the established significance threshold (P = 8.04 × 10−7). Journal of Allergy and Clinical Immunology 2018 142, 1662-1665DOI: (10.1016/j.jaci.2018.06.045) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Three-dimensional ribbon representation of the HLA-DR molecule. Amino acid positions associated with idiopathic RPF are highlighted. This figure was prepared by using UCSF Chimera. Journal of Allergy and Clinical Immunology 2018 142, 1662-1665DOI: (10.1016/j.jaci.2018.06.045) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions